ABSTRACT: Resveratrol increases BRCA1 and BRCA2 mRNA expression
    in breast tumour cell lines
    [07/04/2003; British Journal of Cancer]

The phytochemical resveratrol, found in grapes, berries and peanuts,
has been found to possess cancer chemopreventive effects by inhibiting
diverse cellular events associated with tumour initiation, promotion
and progression. Resveratrol is also a phyto-oestrogen, binds
to and activates oestrogen receptors that regulate the transcription
of oestrogen-responsive target genes such as the breast cancer
susceptibility genes BRCA1 and BRCA2. We investigated the effects
of resveratrol on BRCA1 and BRCA2 expression in human breast
cancer cell lines (MCF7, HBL 100 and MDA-MB 231) using quantitative
real-time RT-PCR, and by perfusion chromatography of the
proteins. All cell lines were treated with 30 M resveratrol.
The expressions of BRCA1 and BRCA2 mRNAs were increased although
no change in the expression of the proteins were found. These
data indicate that resveratrol at 30 M can increase expression
of genes involved in the aggressiveness of human breast tumour
cell lines. 

The full article can be found at:

http://www.nature.com/cgi-taf/DynaPage.taf?file=/bjc/journal/v89/n1/abs/6600983a.html

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