Just when you think you have this diet thing figured out, along comes a
zinger to disrupt everything. This study suggests that increases in HDL seen
after higher fat diets might not indicate an increase in reverse transport of
cholesterol afterall.
J Nutr 2002 Jan;132(1):50-4 Related Articles, Links
Dietary fat saturation affects apolipoprotein AII levels and HDL composition
in postmenopausal women.
Sanchez-Muniz FJ, Merinero MC, Rodriguez-Gil S, Ordovas JM, Rodenas S, Cuesta
C.
Departamento de Nutricion, Universidad Complutense de Madrid, Madrid, Spain.
[log in to unmask]
Increased HDL-cholesterol levels have been associated with lower coronary
heart disease (CHD) risk. However, HDL are heterogeneous lipoproteins, and
particles enriched in apolipoprotein (Apo) AII have been associated with
increased CHD risk. We examined the effect of dietary intervention on HDL
composition in 14 postmenopausal women subjected to two consecutive diet
periods, i.e., an oleic acid sunflower oil diet followed by a palmolein diet,
each lasting 4 wk. The linoleic acid was kept at 4% total energy and the
cholesterol intake at 400 mg/d. The palmolein diet increased serum total
cholesterol (TC) (P < 0.001), phospholipids (P < 0.001), Apo AII (P < 0.001),
HDL cholesterol (P < 0.05), HDL lipids (P < 0.05), HDL proteins (P < 0.01)
and the HDL total mass (P < 0.05). The HDL cholesterol/Apo AI ratio was
increased 22.0% (P < 0.05), whereas the HDL cholesterol/Apo AII and the Apo
AI/Apo AII ratios were decreased 19.4% (P < 0.01) and 30.4%, (P < 0.001),
respectively. When the effects of the dietary intervention were examined
according to the cholesterolemia status (< or >6.2 mmol/L), the most
significant changes (P < 0.001) were related to Apo AII levels. Moreover, a
significant dietary oil by cholesterol level interaction was found for Apo
AII and the HDL cholesterol/Apo AII ratio. In summary, a palmolein diet
increased TC and HDL cholesterol compared with oleic acid sunflower oil diet;
however, the increase in Apo AII but not in Apo AI suggests the impairment of
reverse cholesterol transport and potentially an increase in CHD risk. This
effect was more marked in women with serum TC > 6.2 mmol/L.
Namaste, Liz
<A HREF="http://www.csun.edu/~ecm59556/Healthycarb/index.html">
http://www.csun.edu/~ecm59556/Healthycarb/index.html</A>
|