My 100% raw food vegan/hygiene friend asks another question of the Paleo
list:....

2. It is well documented in the medical and health literature that excess
fat in the blood and tissues makes the body "insulin-resistant" .   Whereas
refined and cooked sugars stress the pancreas in having to produce a lot of
insulin to clear the surge of sugar from the blood, excess fat stresses the
pancreas by making the cells more resistant to the uptake of insulin, which
means that the pancreas has to produce more insulin to make up for the
insulin-resistance.  The paleolithic diet has a very high fat intake (in
excess of 100 grams of fat per day).  Isn't the high fat intake going to
compound blood sugar metabolism problems, by making the body more
"Insulin-resistant", thus leading to "pancreatic poop-out" over time?   It
is well known in health literature that when diabetics lose weight by
changing to a low fat, no animal product diet and a unrefined, uncooked
sugar intake, that their pancreas recovers and usually they are off all
insulin in a couple of months.