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Subject:
From:
Todd Moody <[log in to unmask]>
Date:
Tue, 31 Oct 2000 09:50:41 -0500
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On Mon, 30 Oct 2000, Cave Chick wrote:

> Thanks for the response Todd.  Any suggestions on where I could read up more
> on LDL elevation following rapid weight loss in women?

Sure, right here...

Todd Moody
[log in to unmask]

Title
       The transient hypercholesterolemia of major weight loss.

Author
       Phinney SD; Tang AB; Waggoner CR; Tezanos-Pinto RG; Davis PA

Source
       Am J Clin Nutr, 1991 Jun, 53:6, 1404-10

Abstract
       Serum lipoproteins, body composition, and adipose
       cholesterol contents of six obese women were studied
       during and after major weight loss by very-low-calorie
       diets (VLCDs). Subjects started at 168 +/- 11% of ideal
       body weight, lost 30.3 +/- 3.7 kg in 5-7 mo, followed by
       2+ mo in weight maintenance.  Serum cholesterol fell from
       a prediet (baseline) value of 5.49 +/- 0.32 to 3.62 +/-
       0.31 mmol/L (P less than 0.01) after 1-2 mo of VLCDs
       (nadir), after which it rose to 5.95 +/- 0.36 mmol/L
       (peak, P less than 0.01 compared with nadir and baseline)
       as weight loss continued. With weight maintenance, serum
       cholesterol fell to 4.92 +/- 0.34 mmol/L (P less than 0.05
       compared with peak).  Adipose cholesterol content did not
       change in peripheral (arm and leg) biopsy sites but rose
       significantly in abdominal adipose tissue with weight
       loss. We conclude that major weight loss was associated
       with a late rise in serum cholesterol, possibly from
       mobilization of adipose cholesterol stores, which resolved
       when weight loss ceased.

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