I found this 1995 article a few weeks ago when I was feeling really
bone-tired for days on end that stretched into weeks and decided to look up
some of the causes of fatigue.  Since I had already begun questioning
whether there's a need to supplement while eating a very paleo diet, I quit
taking everything except the EPA/DHA I mentioned in an earlier post.  The
jury is still out on whether I feel any *great* improvement from ditching
the supplements but there does seem to be some mild improvement.  Whether
the fatigue is/was related to the rather high level of antioxidants I was
taking is open to question, but I wonder whether any other paleo-dieters out
there have ever experienced a marked increase in fatigue at some point after
going on a paleo diet.

Theola

 http://www.thenutritionreporter.com/Free-rads.html

EXCERPTS:

[T]he vitamins I took should have left me feeling absolutely energized.
That's what the research says. And what the advertising for antioxidant
supplements often suggests. But over the past 10 years or so, I've felt far
more fatigued than I should have. Tired in the morning. Tired in the
afternoon. Tired in the evening but, I should note, not suffering from
crippling Chronic Fatigue Syndrome.

It wasn't easy finding the answers. But I eventually tracked down the person
who would know them: Denham Harman, M.D., Ph.D. He's the fellow who
conceived the free radical theory of aging back in November 1954.

To my surprise, I discovered that I was doing too good of a job quenching
those dangerous free radicals we all hear about. I was taking too many
antioxidants.
In talking with Harman, I learned that the relationship between free
radicals and antioxidants was really one of balance. Now "retired" and
professor emeritus of medicine at the University of Nebraska, Omaha, Harman
spends at least five full days each week in his office and regularly
publishes articles in medical journals. He has a lot of energy for a man
about to turn 80.

In one of our phone conversations, I asked Harman which supplements he took.
Unlike a lot of doctors who don't want to go on record revealing this
information, Harman was forthright: 400 IU. vitamin E, 2,000 mg. vitamin C,
100 mcg. selenium, and 30 mg. coenzyme Q10 each day and 25,000 IU of
beta-carotene every other day.  "I'd take more," he said, "but I can't
afford to be fatigued."

My ears perked up. "Fatigued?" I asked.

Harman explained that excessive antioxidants could cause fatigue and muscle
weakness.

Harman feels that people can still overdo antioxidants.

"Too many antioxidants can leave you feeling very weak," Harman said

I asked Harman whether too many natural antioxidants could also cause
fatigue.

Harman was unequivocal. Yes.

Just as some experiments have shown that vitamin E supplements increase
stamina, there's a point of diminishing returns. And I had inadvertently hit
that point.