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Subject:
From:
Ron Hoggan <[log in to unmask]>
Reply To:
Paleolithic Eating Support List <[log in to unmask]>
Date:
Fri, 24 Sep 2010 18:39:44 -0700
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  Hi Trish,
As a type II diabetic you have little risk of developing ketoacidosis. 
Here is a direct quote from a paper by Anssi H. Manninen that appeared 
in Journal of the International Society of Sports Nutrition. 1(2):7-11, 
2004. (www.sportsnutritionsociety.org) under the title "METABOLIC 
EFFECTS OF THE VERY-LOW-CARBOHYDRATE DIETS: MISUNDERSTOOD “VILLAINS” OF 
HUMAN METABOLISM"


DIABETIC KETOACIDOSIS VS. DIETARY KETOSIS
Diabetic patients know that the detection in their urine of the ketone 
bodies is a danger signal that their diabetes is poorly controlled. 
Indeed, in severely uncontrolled diabetes, if the ketone bodies are 
produced in massive supranormal quantities, they are associated with 
ketoacidosis. In this life-threatening complication of diabetes 
mellitus, the acids 3-hydroxybutyric acid and acetoacetic acid are 
produced rapidly, causing high concentrations of protons, which 
overwhelm the body’s acid-base buffering system. However, during very 
low carbohydrate intake, the regulated and controlled production of 
ketone bodies causes a harmless physiological state known as dietary 
ketosis. In ketosis, the blood pH remains buffered within normal limits. 
Ketone bodies have effects on insulin and glucagon secretions that 
potentially contribute to the control of the rate of their own formation 
because of antilipolytic and lipolytic hormones, respectively. Ketones 
also have a direct inhibitory effect on lipolysis in adipose tissue. 
Interestingly, the effects of ketone body metabolism suggest that mild 
ketosis may offer therapeutic potential in a variety of different common 
and rare disease states . The large categories of disease for which 
ketones may have therapeutic effects are: 1) diseases of substrate 
insufficiency or insulin resistance; 2) diseases resulting from free 
radical damage; and 3) disease resulting from hypoxia.

This is an unfortunate myth that has its roots in many medical students 
being taught that the terms ketosis and ketoacidosis are the same thing.

I hope that helps.
best wishes,
Ron


-- 
PK

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