-I saw that post on an other list and because we are talking about soya ,i
send it here.
In case you needed more argument.
jean-claude--
-Original Message-----
From: Mark Graffis <[log in to unmask]>
To: graffis-l <[log in to unmask]>; [log in to unmask]
<[log in to unmask]>
Date: 27 November 1999 23:37
Subject: SOY WARNING!


>
>Date: Sat, 27 Nov 1999 15:32:51 -0500
>From: Ian Goddard <[log in to unmask]>
>To: [log in to unmask]
>Subject: SOY WARNING!
>
>
>  SOYBEANS LINKED TO BRAIN ATROPHY AND CELL DEATH
>
>  As a vegetarian, I present the following with great regret.
>  Soy products like tofu have provided the staple alternative
>  to eating murdered animals. Unfortunately the study reported
>  here: http://starbulletin.com/1999/11/19/news/story4.html
>  has found a significant link between eating tofu and brain
>  aging and atrophy! My first reaction was to hope that the
>  study was flawed. Unfortunately, a quick study of published
>  research at the National Library of Medicine indicates that
>  there is a STRONG physiological basis for the findings in
>  that study. It seems that a main phytochemical in soybeans,
>  genistein, reduces DNA synthesis in the brain, and reduced
>  DNA synthesis promotes apoptosis, which is also known as
>  "programmed cell death." Multiple studies I found indicate
>  that drug-induced reduction of DNA synthesis is routinely
>  assoicated with reduced cell proliferation and death. DNA
>  synthesis is a critical part of the life cycle of a cell:
>  http://www.geocities.com/CollegePark/Lab/1580/cycle2.gif
>  http://www.geocities.com/CollegePark/Lab/1580/cycle.html
>
>  It appears that the ability of genistein to reduce DNA
>  synthesis may be why it is a promising anti-cancer agent,
>  for research suggests genistein can kill cancer cells and
>  other drugs that reduce DNA synthesis kill cancer cells.
>  Unfortunately, genistein's cytotoxic properties appear
>  to be nonspecific, ie, it doesn't only kill cancer cells.
>  In the first abstract below, it was found that genistein
>  "induced significant testicular cell death." Ouch! The
>  second study finds that genistein reduced DNA synthesis
>  in the brain. To get the full picture of what I've stated
>  here, I recommend using the National Library of Medicine's
>  search engine: http://www.ncbi.nlm.nih.gov/PubMed  It is
>  easily the most powerful tool on the Internet, accessing
>  most of the published medical research since around 1965.
>
>    Too much tofu induces ‘brain aging,’ study shows:
>   http://starbulletin.com/1999/11/19/news/story4.html
>
>
>=================================================================
>Soy-phytochemical genistein "induced significant testicular cell
>death."
>
>Biol Cell 1999 Sep;91(7):515-23
>
>Cytotoxic potential of the phytochemical genistein
>isoflavone (4',5',7-trihydroxyisoflavone) and certain
>environmental chemical compounds on testicular cells.
>
>Kumi-Diaka J, Nguyen V, Butler A
>
>Florida Atlantic University, Department of Biology,
>College of Liberal Arts & Sciences, Davie 33314, USA.
>
>[Medline record in process]
>
>The effects of genistein (Gn), sodium azide (naz), and
>dexamethasone (dxm) on testicular cells TM3, TM4 and
>GC-1 spg were studied in vitro. First, a series of
>experiments were performed to assess the response of
>the cells to the exposure of Gn, naz, dxm, a combination
>of Gn with naz and Gn with dxm. Trypan blue exclusion
>assay was used to determine the percentage of viability,
>and LDH-cytotoxicity test was used to assess the degree
>of treatment-induced cytotoxicity on each cell type. A
>second series of experiments were performed to study
>cytomorphology and determine the type and percentage of
>treatment-induced cell death (apoptosis and necrosis) on
>each cell line, using fluorescent dye technique to detect
>apoptotic and necrotic cells, and tunnel assay to confirm
>apoptosis. The results from the data obtained demonstrated:
>i) that incubation of testis cells with each of the agents
>(Gn, dxm, naz) alone and in two combinations (Gn-dxm, and
>Gn-naz) induced significant testicular cell death; ii) that
>both genistein and dexamethasone mostly and significantly
>induced apoptotic cell death while sodium azide induced
>necrotic cell death; iii) that addition of dexamethasone
>to genistein demonstrated synergism in apoptosis on testis
>cells; and iv) that combination of naz with Gn demonstrated
>synergism in necrosis on testis cells even though Gn alone
>did not induce significant necrosis. It is concluded that
>the synergistic actions of genistein and dxm, and of genistein
>+ sodium azide in induction of apoptosis and/or necrosis may
>be of clinical and pathophysiological research interest
>considering the chemopreventive and chemotherapeutic potential
>of genistein; and the clinico-pharmacological application of
>dexamethasone and sodium azide.
>
>http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10572627&form=6&db=
m
>&Dopt=b
>
>
>===============================================================
>"Genistein decreased the DNA synthesis within less than 30 min."
>
>Exp Neurol 1999 Sep;159(1):164-76
>
>Early effects of protein kinase modulators on DNA synthesis
>in rat cerebral cortex.
>
>Yakisich JS, Siden A, Vargas VI, Eneroth P, Cruz M
>
>Applied Biochemistry, Clinical Research Center, Karolinska
>Institute, Novum, Huddinge University Hospital, Huddinge,
>S-141 86, Sweden.
>
>By using tissue miniunits, protein kinase modulators, and
>topoisomerase inhibitors in short-term incubation (0-90 min)
>we studied (1) the role of protein phosphorylation in the
>immediate control of DNA replication in the developing rat
>cerebral cortex and (2) the mechanism of action for genistein-
>mediated DNA synthesis inhibition. Genistein decreased the DNA
>synthesis within less than 30 min. None of the other protein
>kinase inhibitors examined (herbimycin A, staurosporine,
>calphostin-C) or the protein phosphatase inhibitor sodium
>orthovanadate inhibited DNA synthesis and they did not affect
>the genistein-mediated inhibition. The selective topoisomerase
>inhibitors camptothecin and etoposide decreased the DNA synthesis
>to an extent similar to that of genistein and within less than
>30 min. In addition, the effects of these substances on
>topoisomerase I and II were studied. Etoposide and genistein
>but not herbimycin A, staurosporine, or calphostin-C strongly
>inhibited the activity of topoisomerase II. Our results (1)
>strongly suggest that the net rate of DNA replication during
>the S phase of the cell cycle is independent of protein
>phosphorylation and (2) indicate that the early inhibitory
>effect of genistein on DNA synthesis is mediated by
>topoisomerase II inhibition rather than protein tyrosine
>kinase inhibition. Copyright 1999
>Academic Press.
>
>http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10486185&form=6&db=
m
>&Dopt=b
>
>
>============================================================
>Reduce DNA synthesis associated with aging
>
>Acta Neuropathol (Berl) 1999 Jan;97(1):71-81
>
>Age-related changes of DNA repair and mitochondrial
>DNA synthesis in the mouse brain.
>
>Schmitz C, Axmacher B, Zunker U, Korr H
>
>Department of Anatomy and Cell Biology, RWTH University
>of Aachen, Germany. [log in to unmask],de
>
>Using quantitative autoradiography, both nuclear DNA
>repair - measured as nuclear unscheduled DNA synthesis
>(UDS) - and mitochondrial (mt) DNA synthesis were
>evaluated in situ for several types of cells in the
>brains of untreated mice of various age. It was found
>that distinct types of neuronal cells showed a decline
>of both UDS and mtDNA synthesis with age, whereas -
>except for glial cells of the cerebral cortex - no glial
>or endothelial cells showed age-related alterations of
>UDS. Together with various data reported in the literature,
>these patterns of a cell type-specific decrease of UDS and
>mtDNA synthesis with age in the mouse brain lead to an
>improved understanding of the complex interrelationships
>between the molecular events associated with the
>phenomenon of aging as well as to a new idea regarding
>the cause of the specific distribution pattern of those
>cells in the human brain that are affected by the formation
>of paired helical filaments in Alzheimer's disease.
>
>http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9930897&form=6&db=m
&
>Dopt=b
>=========================================================
>
>To get the full picture of what I stated above, I
>recommend using the National Library of Medicine's
>search engine: http://www.ncbi.nlm.nih.gov/PubMed
>The key words you choose make all the difference!
>
>------------------------------------------------------------
>GODDARD'S JOURNAL: http://www.erols.com/igoddard/journal.htm
>____________________________________________________________
>
>
>