Over 20 years ago, the psychiatrist Egon Haberfellner attempted to 
recruit patients for a planned clinical trial of antidepressant 
medication from his community practice. He discovered that only one 
of the 216 patients with depression that he treated over a 6-month 
period in his clinic was eligible to participate. As a diplomatic 
understatement, he concluded that "study results obtained under 
restrictive inclusion and exclusion criteria are probably only 
applicable to a proportion of patients treated under routine conditions".

http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30512-6/fulltext



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