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Mon, 13 Apr 1998 16:35:36 +0700
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<<Disclaimer: Verify this information before applying it to your situation.>>

                         Report on QUESTIONS 2

  12 list members responded QUESTIONS 2. 11 of them were predisposed to
different kinds of allergic reactions and had gastro-intestinal problems.
Many of them reported improvement of allergic condition on GF diet. Thus, this
group had "celiac-like syndrome".

                        Table 1. Comparison of celiac and celiac-like
                        patients.
                        Celiac group          Celiac-like group
 G1:  36 G2:  12        N1    í1  +/- m1      N2    í2  +/- m2     t

Celiac  disease         36 100.000   0.000    12   0.000   0.000

Patch-shaped
foci of hyperkeratosis  33  27.273   7.873    12   0.000   0.000 P<0.05

Visible steatorrhoea    36  52.778   8.438    12  16.667  11.237 P<0.05


  Thus, celiacs had more steatorrhoea (stool leaves traces) - a sign of
malabsorption and patch-shaped hyperkeratosis.

  It is possible to suggest that pathogenesis of allergy (at least some forms
of allergy) involves some mechanisms common with pathogenesis of celiac
disease.

   Dear list members, I know that you are tired of my QUESTIONS, but to finish
this investigation I want to collect a group of people without diagnosed CD
and without significant allergic reactions. To help this, please, ask your
relatives or friends to respond QUESTIONS 3.

   Michail Valivach, MD

                     QUESTIONS 3


  1. Name (or pseudonym).  Sex.
  2. Birth date
     Stature
     Weight
  3. Please, confirm that you are not a celiac and not predisposed to allergic
reactions
  4. Do you have chronic (lasting more than 2 months) of frequent (more
than 4 episodes in a year) infectious and noninfectious inflammatory diseases?
                                 Yes, No, I can not answer

         If "Yes", please answer the following questions:
         a. Do you have chronic or frequent respiratory infections?
                                 Yes, No, I can not answer

               If so, are you easily infected during epidemics
                                 Yes, No, I can not answer

                      and/or you have your own chronic or relapsing infection
                      (for instance, chronic bronchitis, tonsillitis etc)
                                 Yes, No, I can not answer
                      List the infections:



         b. Do you have or had asthma?
                                 Yes, No, I can not answer


  5. Do you have any skin diseases?
                                 Yes, No, I can not answer

                   If "Yes", please, list their diagnoses:

  6. Are you predisposed to allergic reactions?
                                 Yes, No, I can not answer

                   If "Yes", please, give more information


  7. Do you have any diseases of the digestive system (additionally
to CD)?
                                 Yes, No, I can not answer

                    Please, list them:

  9. The highest body temperature during the last 3 years:

  10. Are you predisposed to long lasting (more than 14 days) fever?
                                 Yes, No, I can not answer

  11. Fatigue

  12. Please, describe you skin. Do you have:

   a. Constant or episodic hair loss
                                 Yes, No, I can not answer

   b. Dry or tarnished hair
                                 Yes, No, I can not answer

   c. Early turning gray (before 30)
                                 Yes, No, I can not answer

   d. Predisposition to dandruff
                                 Yes, No, I can not answer

   e. Fragility of the nail walls
                                 Yes, No, I can not answer

   f. Fragility of the nails
                                 Yes, No, I can not answer

   g. Dryness of the lips
                                 Yes, No, I can not answer

   h. Cyanosis of the lips
                                 Yes, No, I can not answer

   i. General skin dryness
                                 Yes, No, I can not answer

   j. Dryness and/or scaling and/or irritation

         - in the nasolabial region
                                 Yes, No, I can not answer
         - of the elbows and/or knees
                                 Yes, No, I can not answer
         - above the brows (including dandruff) and/or around the eyes
                                 Yes, No, I can not answer
         - of the hands (especially after water exposure)
                                 Yes, No, I can not answer
         - of the cheeks
                                 Yes, No, I can not answer
         - of the nose
                                 Yes, No, I can not answer
         - of the ears
                                 Yes, No, I can not answer

   k. Follicular hyperkeratosis (perifollicular accentuation). That
means small dry skin elevations around the hair follicles.
                                 Yes, No, I can not answer

   l. Cyanotic, marbled skin
                                 Yes, No, I can not answer

   m. Scaling dermatitis (like eczema)
                                 Yes, No, I can not answer

   n. Red spots with dryness and/or scaling and/or irritation
                                 Yes, No, I can not answer

   o. Predisposition to acne (black heads)
                                 Yes, No, I can not answer

   p. Bad tolerance to sun burns
                                 Yes, No, I can not answer

   q. Skin itching
                                 Yes, No, I can not answer

   r. Chronic skin candidiasis (yeast infection)
                                 Yes, No, I can not answer

   s. Feet cyanosis
                                 Yes, No, I can not answer

   t. Patch-shaped foci of hyperkeratosis (foci of dry and thick skin)
                                 Yes, No, I can not answer

    13. Please, describe the tongue:

   a. Enlarged tongue with the teeth imprints
                                 Yes, No, I can not answer

   b. Smooth ("polish") tongue
                                 Yes, No, I can not answer

   c. Hypertrophy of the tongue papillae (small round elevations)
                                 Yes, No, I can not answer

   d. Dry bright-red tongue
                                 Yes, No, I can not answer

   e. Cracks or folds on the tongue
                                 Yes, No, I can not answer

   f. Irritation and/or brown cover of the tongue base
                                 Yes, No, I can not answer

   g. Dryness of the mucous membranes
                                 Yes, No, I can not answer

   h. Gum bleeding after teeth brushing
                                 Yes, No, I can not answer

    14. Gastrointestinal tract:

   a. Unpleasant smell from the mouth
                                 Yes, No, I can not answer

   b. Pains in the tip of the stomach
                                 Yes, No, I can not answer

   c. Heartburn
                                 Yes, No, I can not answer

   d. Sour and/or bitter and/or nasty belch
                                 Yes, No, I can not answer

   e. Unpleasant sensations below the ribs on the right
                                 Yes, No, I can not answer

   f. Unpleasant sensations below the ribs on the left
                                 Yes, No, I can not answer

   g. Pains in the upper abdomen or nausea on fasting
                                 Yes, No, I can not answer

   h. Feeling bloated after moderate amounts of food
                                 Yes, No, I can not answer

   i. Intestinal murmur after food
                                 Yes, No, I can not answer

   j. Intestinal murmur after milk
                                 Yes, No, I can not answer

   k. Hemorrhoids
                                 Yes, No, I can not answer

   l. Liquid or semi-liquid stool very often
                                 Yes, No, I can not answer

   m. Intensive urges to defecate
                                 Yes, No, I can not answer

   n. Stool leaves traces on the lavatory bowl
                                 Yes, No, I can not answer

   o. Undigested food in stool very often
                                 Yes, No, I can not answer

   p. Fragmented ("sheep's") stool
                                 Yes, No, I can not answer

   q. Constipation
                                 Yes, No, I can not answer

   r. Stool with sour smell
                                 Yes, No, I can not answer

   s. Stool with rotten smell
                                 Yes, No, I can not answer

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