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Subject:
From:
Roy Jamron <[log in to unmask]>
Reply To:
Roy Jamron <[log in to unmask]>
Date:
Fri, 25 Jul 2008 18:31:34 -0400
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<<Disclaimer: Verify this information before applying it to your situation.>>

Be careful when claiming a "cause" for celiac disease.  The Gastroenterology
article upon which the news story is based implying a possible cause for celiac
disease makes no claim of finding a "cause".  It only concludes that
"gliadin binds to CXCR3 and leads to MyD88-dependent zonulin release and
increased intestinal permeability."  Zonulin release due to CXCR3 binding is
only "a postulated early element in the pathogenesis of celiac disease", not
a "cause".  The study also found "mucosal CXCR3 expression was elevated in
active celiac disease but returned to baseline levels following implementation
of a gluten-free diet", so that CXCR3 expression is NORMAL before the onset
of celiac disease.  Something else other than zonulin triggers the onset of
celiac disease.  If something is a cause of celiac disease, then it also must
explain why one identical twin may experience celiac disease and not the
other twin.  Zonulin and CXCR3 cannot explain this because both twins have
this same mechanism and the same genetic susceptibility to celiac disease.
There have to be factors which differ between the twins and cause the onset
of celiac disease.

Gastroenterology Volume 135, Issue 1, Pages 194-204.e3 (July 2008)
Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by
Binding to the Chemokine Receptor CXCR3
Alessio Fasano, et al.
http://www.gastrojournal.org/article/S0016-5085(08)00459-9/abstract

* * *

* Please remember some posters may be WHEAT-FREE, but not GLUTEN-FREE *
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