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Subject:
From:
Ron Hoggan <[log in to unmask]>
Date:
Sat, 21 Jul 2001 13:25:40 -0600
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<<Disclaimer: Verify this information before applying it to your situation.>>

Hi Cindy,

I am posting to the list as I suspect that others may be concerned about the
same issue.

In Kamran Rostami's Ph.D. thesis, University of Amsterdam, 1998 (chapter 4,
page 58 )

**************************************************

 "Conclusion: A negative result for EMA in coeliacs with normal IgA
value doesn't exclude the diagnosis of CD. A positive EMA is seen mostly
in those coeliacs with severe tissue damage (SVA/TVA). EMA has a low
sensitivity in coeliacs with PVA in spite of use of of different substrates."

SVA= sub-total villous atrophy
TVA= total villous atrophy
PVA= partial villous atrophy

**************************************************

There is little doubt that positive endomysium antibody test results are
diagnostic for celiac disease. Those who do not show villous damage will
do so in the very near future if they continue to consume gluten.
However, a negative blood test should not exclude celiac disease. Dr.
Chris Mulder has reported that more than 30% of celiacs with mild
villous atrophy will be missed with blood tests. I have misplaced the
paper in question, so I can't cite it.

I my comments prove helpful.
best wishes,
Ron

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