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May I suggest that you might be getting small amounts of gluten? Marsh
et. al. have demonstrated microvascular leakage at the site of rectal-gluten
challenge, in celiac patients.
> the next 1 and 1/2 hours trying to control the out
>of control bleeding I was doing in order to put me back together. They
>immediately did clotting tests and mine were all normal, but I was even
>having occassional nose bleeds with very bright bleeding. I had had
>surgery in June without any bleeding problems. Anyone have any ideas?
If you have been getting gluten in your diet, there is some evidence
to suggest intestinal bleeding is common among celiacs ingesting gluten.
It was reported in a NEJM article earlier this year, but I can't put my
hand on the article just now.
> All
>the Dr's asked about my CD. They gave me large doses of Vit K in the OR,
>but without any changes(but normally would take 24-48 hrs for changes). I
>am to see a haemotologist. I also have lost large amounts of hair
>recently.
The hair loss might also suggest gluten ingestion via increased
circulating antibodies, and molecular mimicry. (This is a hypothesis where
the antibodies to substances from outside the body are developed, and the
antigen is similar, in molecular structure, to self-tissues that an
autoimmune attack ensues.)
Alterations in cholesterol, and sex hormone-binding globulins have also been
associated with gluten ingestion (Gates). There is a very complex
constellation of possibilities, many of which are suggestive of gluten.
An antibody test might shed some light on your current g-f status.
I am not a doctor. These are the musings of a fellow celiac, but I hope
they are helpful.
Sincerely,
Ron Hoggan
References:
1. Marsh MN, _Immunopathology of the Small Intestine_ John Wiley & Sons,
Toronto, 1987; pages 374-377.
2. Ensari, et. al. "Time-course adhesion molecule expression in rectal
mucosa of gluten-sensitive subjects after gluten challenge" Clin Exp
Immunol 1993; 92: 303-307.
3. Marsh, MN "Gluten, Major HIstocompatibility Complex, and the Small
Intestine" Gastroenterology 1992; 102: 330-354.
4. Ronda et. al. "Selectivity of recognition of variable (V) regions
of autoantibodies by intravenous immunoglobulin (IVIg)" Clinical
Immunology & Immunopathology 1994; 70(2): 124-128.
5. Van der Wal, et. al. "Adhesion molecules on the endothelium and
mononuclear cells in human atherosclerotic lesions" Am J Pathology
1992; 142(6): 1427-1433.
6. Davies et. al. "The expression of the adhesion molecules ICAM-1,
VCAM-1, PECAM, and E-selectin in human atherosclerosis" Journal of
Pathology 1993; 171(3): 223-229.
7. Languino, et. al. "Regulation of leukocyte-endothelium interaction
and leukocyte transendothelial migration by intercellular adhesion
molecule 1-fibrinogen recognition" Proceedings of the National
Assembly of Sciences of the United States of America 1995; 92(5):
1505-1509.
8. Lutz WJ "The Colonisation of Europe and Our Western Diseases"
Med Hypoth 1995; 45: 115-120.
9. Vuoristo, et. al. "Metabolism of Cholesterol and Apolipoprotein B in
Celiac Disease" Metabolism 1993; 42(11): 1386-1391.
10 Gates et. al. "Association of dietary factors and selected plasma
variables with sex hormone-binding globulin in rural Chinese women"
Am J Clin Nutr 1996; 63: 22-31.
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