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The researchers report in the February issue of the Journal of Tropical
Pediatrics that serum prolactin levels were significantly elevated in children with
active celiac disease. Mean prolactin levels were 48.3 ng/mL in active celiac
disease, 18.3 ng/mL in children in remission and 9.3 ng/mL in controls.
Prolactin levels were higher among those with long standing disease, with
mean levels of over 75 ng/mL recorded among those with celiac disease for more
than 5 years. Levels also positively correlated with the severity of villous
atrophy, the pathognomic feature of celiac disease, the investigators point out.
The researchers conclude that serum prolactin, because of its positive
correlation with disease activity, can be used as an "additional marker of disease
activity...and may be a more viable option economically" than use of other
markers  http://www.medscape.com/viewarticle/471665?mpid=26286
Rosalie (NJ)

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