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PrometheusLabs.com Contact UsBelow is a reply from Prometheus labs. They do indeed include the A*0201 allele in their test. Dr. Fine does not.
Hilary
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To: [log in to unmask] 
Sent: Tuesday, October 21, 2003 7:11 PM
Subject: PrometheusLabs.com Contact Us




-----Original Message----- 
From: Kathy Strahorn 
Sent: Tuesday, October 21, 2003 3:39 PM 
To: Melanie Adams 
Subject: RE: PrometheusLabs.com Contact Us 
Importance: High 



Thank you for your inquiry. We are not aware of the specifics of LabCorp HLA testing, but we do know that not all testing is done to the same resolution (or detail).  Our DQ2 tests for A1*05, B1*02, and A1*0201. The DQ8 tests for B1*0302.

Our specimen requirement is one tube of EDTA whole blood. 

Below are some additional comments from our Celiac product manager: 

We believe we have an excellent celiac genetic test which does include the A0201 allele.  The power of the genetic test is when it is negative.  That means, if her son tests negative for this test, he will never develop celiac in his lifetime.  If he does test positive for one or both haplotypes (30% of the population will) it doesn't mean that he will develop celiac, it's just that it is possible.  

(THE COMPREHENSIVE CELIAC SYSTEM IS ONLY INDICATED IF YOUR SON IS EATING GLUTEN) If she is considering doing celiac testing in general, recommend the Comprehensive celiac disease system.  This means if he tests positive for the 5 panel assay (very important to have EMA, tTG and Total Serum) and if that is negative have it automatically reflex to the genetic test.  If that is negative - he can eat gluten again and not worry about celiac.  If the serology is positive - he is celiac.  He is either ruled-in celiac or ruled-out for celiac all in one blood draw (2-tubes)  This is the best!

If her doctor is doing serological testing be sure he gets EMA, tTG and Total Serum!  Most labs do not use all three and she doesn't want to miss anything. When performing EMA, be sure they are using a lab like ours that has trained technologists that can perform the EMA - it is subjective to the technologist interpretation!

I hope this information will be helpful.  Please let me know if you have further questions. 

Kathy Strahorn 
Client Service Manager 

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Sent: Sunday, October 19, 2003 7:04 AM 
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Subject: PrometheusLabs.com Contact Us 



The following comments were submitted by [log in to unmask] 

I am looking for genetic testing for Celiac Disease for my son. I want to cast as wide a net as possible (clinical diagnosis, prior gluten challenge disaster, do not want to miss any possible "proof" which will satisfy him to stay gluten free). It is my understanding that there is a new HLA allele (A*0201) which is positive even for those with negative DQ2/DQ8 who are biopsy-proven celiac patients. Does Prometheus labs test for DQ2/DQ8 and A*0201? (reference: Am. J of Gastro, 98:9 Sept. 2003). Are there other Celiac Disease associated genes that you test for? (Lab Corp of America seems to test for a lot of things at a high price, but it is not clear to me that these are directly implicated in CD ("all DR +DQ, all HLA/HLB"). My local doctors office is happy to comply with serological or mouth swab testing. Any information you can provide would be very much appreciated. Thanks. Hilary Shughart

* Visit the Celiac Web Page at www.enabling.org/ia/celiac/index.html *