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Subject:
From:
Roy Jamron <[log in to unmask]>
Reply To:
Roy Jamron <[log in to unmask]>
Date:
Thu, 3 Apr 2003 01:23:02 -0500
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<<Disclaimer: Verify this information before applying it to your situation.>>

Here are 2 new interesting articles:

--------------
This article summarizes the current research on celiac disease.  The full
article is available at medscape.com.  You must be registered (free) with
Medscape to read it.

Curr Opin Gastroenterol 19(2):118-129, 2003
New Developments in Celiac Disease
Jason S. R. Jennings, MRCP, Peter D. Howdle, MD, FRCP

Abstract
Celiac disease remains a challenge to the clinician and scientist. It is
clearly more prevalent than was previously suspected. Much interest is seen
in identifying the genetic factors, which predispose to disease and the
environmental agents that can trigger it. Genome-wide searches have
identified a number of chromosomal susceptibility loci. Specific gliadin
epitopes are being analyzed. New diagnostic options include the tissue
transglutaminase enzyme-linked immunosorbent assay. Neurologic disease and
bone disease are intriguing complications of celiac disease and are
gradually being defined.

http://www.medscape.com/viewarticle/450313

--------------
This looks like a great article for those with some grasp of immunology.
The abstract and summary are free, but the full online article costs $25 if
you don't have access to a subscription site.  I haven't coughed up the $25
to read it, but the next time I get to the University library (some day...
it's a long drive) I'll be sure to print myself a copy.

Nature Reviews Immunology April 2003 Vol 3 No 4: 331-341
ANATOMICAL BASIS OF TOLERANCE AND IMMUNITY TO INTESTINAL ANTIGENS
Allan McI. Mowat

Preface
The intestinal immune system has to discriminate between harmful and
beneficial antigens. Although strong protective immunity is essential to
prevent invasion by pathogens, equivalent responses against dietary
proteins or commensal bacteria can lead to chronic disease. These responses
are normally prevented by a complex interplay of regulatory mechanisms.
This article reviews the unique aspects of the local microenvironment of
the intestinal immune system and discuss how these promote the development
of regulatory responses that ensure the maintenance of homeostasis in the
gut.

(This is the correct link, but it wraps on 2 lines that need to be pasted
together.)
http://www.nature.com/cgi-taf/DynaPage.taf?
file=/nri/journal/v3/n4/abs/nri1057_fs.html

(This shorter link will redirect to the above link.)
http://www.nature.com/nri/journal/v3/n4/abs/nri1057_fs.html

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