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-Michael Thorn

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Prometheus Laboratories Introduces Genetic Test to Differentiate Causes of
Lactose Intolerance


SAN DIEGO, May 19 /PRNewswire/ -- Prometheus Laboratories Inc. today
announced that it is introducing the first genetic test to help physicians
identify a specific genetic cause of lactose intolerance in their patients.
This allows the physician to tailor the patient's treatment based upon the
underlying cause of the disorder. The test, PRO-GenoLogix(SM) Lactose
Intolerance, is being launched at Digestive Disease Week (DDW) in Orlando,
Florida, May 17 to May 22, 2003.

"We are excited to introduce the first genetic test to aid in the diagnosis
of lactose intolerance," said James A. Schoeneck, President & Chief
Executive Officer at Prometheus. "PRO-GenoLogix Lactose Intolerance will
allow physicians to individualize treatment of their patients by discerning
whether a patient has a genetic basis for lactose intolerance or if their
symptoms are related to another disease or disorder."

This highly-specific, proprietary genetic test identifies patients with a
certain genetic marker that is associated with lower than normal levels of
the lactase enzyme. Without sufficient lactase, the patient is unable to
break down lactose, the predominant sugar found in milk and other dairy
products. This results in lactose intolerance symptoms such as nausea,
cramps, bloating, gas and diarrhea. However, many other diseases, such as
irritable bowel disease (IBD) and celiac disease, can present with these
same symptoms. Improperly diagnosed and unmanaged, these diseases can lead
to serious complications. Until now, diagnostic methods used to detect
lactose intolerance could not determine the underlying cause, making it
difficult for physicians to customize critical patient treatment.

"This genetic test will be especially helpful in differentiating genetic
lactose intolerance from other diseases with overlapping symptoms thus
eliminating confusion in the diagnostic work-up and therapeutic plan,"
stated David T. Rubin, M.D., Assistant Professor of Medicine, Director of
Clinical Education for Gastroenterology, University of Chicago. "In
addition, this simple, yet accurate blood test, does not require patients to
undergo fasting, dietary restrictions or lengthy sample collection and,
therefore, will likely be better tolerated by patients."

Between 30 and 50 million Americans are lactose intolerant. Currently, no
treatment exists to improve the body's ability to produce lactase, but
symptoms can be controlled through diet and lactase enzyme supplements.

About Prometheus Laboratories

Prometheus Laboratories Inc. is a specialty pharmaceutical company committed
to developing new ways to help physicians individualize patient care. The
Company focuses on the treatment, diagnosis and detection of
gastrointestinal, autoimmune and inflammatory diseases and disorders. The
Company's strategy includes the marketing and delivery of pharmaceutical
products complemented by its proprietary, high-value diagnostic testing
services. By integrating these therapeutic, diagnostic and treatment
monitoring services, Prometheus addresses the full continuum of care,
thereby providing physicians with a comprehensive solution to treat chronic
diseases. Prometheus' corporate offices are located in San Diego,
California. Additional information about Prometheus Laboratories can be
found at www.prometheuslabs.com .

Digestive Disease Week (DDW) is the largest international gathering of
physicians, researchers and academics in the fields of gastroenterology,
hepatology, endoscopy and gastrointestinal surgery. Participating societies
include the American Association for the Study of Liver Diseases (AASLD),
American Gastroenterological Association (AGA), the American Society for
Gastrointestinal Endoscopy (ASGE), and the Society for the Surgery of the
Alimentary Tract (SSAT).

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