<<Disclaimer: Verify this information before applying it to your situation.>>
Thanks to all who responded. Sorry for the delay in summarizing--busy
getting ready for baby :)
Here's my original post:
From my understanding, you can have the genes associated with celiac without
the disease manifesting itself, but if you don't have the genes, you cannot
have celiac disease? Is this 100% correct?
Since I am pregnant and due next month, I want to know whether I will
automatically pass my celiac genes onto my child. Can anyone elucidate upon
this? Please only respond with answers supported by clinical data.
Here's a summary--not all are supported by clinical data:
basic rule of genetic from biology 1 is that if parent each have 2 possible
genes to contribute and the child get one from each, each child will have
only a 1 in 4 chance of inheriting a specific gene...Having more kids,
doesn't change their odds, always 1 in 4 for the single gene. (If you had
the two different genes, only your siblings would be at risk since you can
only pass one along..Unless Dad contributed celiac genes of his own.)
__________
Your child will only have half of your genes the other half will be from the
other parent. Assuming that your partner does not have CD the child only a
chance of getting the genes associated with the disease. Curiously there is
a very small # of people who do have the disease but do not have the gene. I
can't remember the % off the top of my head but less than 1% of those of us
with the disease.
__________
Seems to be two type...single gene passed from 1 parent or the other, or two
different gene, one from each parent. If they get the two separate genes,
then only siblings are at risk...When the single gene, celiac can pop up in
multiple generations and it's possilbe for some kids get a double whammy by
getting this gene from EACH parent.
From the current research, it looks like 1 in 4 could have genes for celiac,
but it also requires a genetic trigger for the gene to be activated. Not
everyone who has genes gets celiac or the incidence would be much higher.
__________
Generally speaking it is genetic. Not in my case. I came back from
Thailand in 1966 with infectious hepatitis then it was T-1 diabetes 1971, DH
1996, CD 1996, Psoriasis in 2000. I have two daughters and three
grandchildren ages 2 - 18. No one in my family has any of these diseases.
This website may explain it officially.
http://www.niddk.nih.gov/health/digest/pubs/celiac/index.htm
__________
inheritance is a difficult question, in part because there isn't "a" gene,
there are various genes in different populations.
recessive:
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=6405504&dopt=Abstract
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=7282774&dopt=Abstract
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=3093956&dopt=Abstract
incompletely penetrant autosomal dominant gene
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=1121023&dopt=Abstract
dominant
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=2060769&dopt=Abstract
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=11892082&dopt=Abstract
dominant and recessive parts
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=6951410&dopt=Abstract
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=6602084&dopt=Abstract
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=6797985&dopt=Abstract
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=3793924&dopt=Abstract
__________
It also appears that exposure to a specific adenovirus containing "protein
sequences similar to those in gluten" can trigger the an immune sytem
response against gluten for those who have no risk factors for celiac.
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