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Subject:
From:
Roy Jamron <[log in to unmask]>
Reply To:
Roy Jamron <[log in to unmask]>
Date:
Sat, 9 Aug 2003 23:22:52 -0500
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<<Disclaimer: Verify this information before applying it to your situation.>>

I don't have free access to this article (it costs $30), but it does look
interesting if you do have access to The Lancet:

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Lancet. 2003 Aug 2;362(9381):383-91

Coeliac disease.

Green PH, Jabri B.

Department of Medicine, Columbia University College of Physicians and
Surgeons, New York, USA

Coeliac disease is a genetically-determined chronic inflammatory intestinal
disease induced by an environmental precipitant, gluten. Patients with the
disease might have mainly non-gastrointestinal symptoms, and as a result
patients present to various medical practitioners. Epidemiological studies
have shown that coeliac disease is very common and affects about one in 250
people. The disease is associated with an increased rate of osteoporosis,
infertility, autoimmune diseases, and malignant disease, especially
lymphomas. The mechanism of the intestinal immune-mediated response is not
completely clear, but involves an HLA-DQ2 or HLA-DQ8 restricted T-cell
immune reaction in the lamina propria as well as an immune reaction in the
intestinal epithelium. An important component of the disease is the
intraepithelial lymphocyte that might become clonally expanded in
refractory sprue and enteropathy-associated T-cell lymphoma. Study of the
mechanism of the immune response in coeliac disease could provide insight
into the mechanism of inflammatory and autoimmune responses and lead to
innovations in treatment.

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