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Another forward from Kalle Reichelt on Autism and Celiac Disease:

Message 11      12/28/94  9:25 AM
From:  Kalle Reichelt,[log in to unmask],Internet

1:   Already Prof Asperger in Austria noticed that many (not all) coeliac
children showed psychiatric problems (Asperger H (1961) Die Psychopathologie
des Coeliakikranken Kindes. Ann. Paediat.197:146-151).   A similar
relationship of malabsorption to autism was also indicated in theUSA (Coleman
M ed: Autistic syndromes .North Holland Press,Amsterdam 1976.)  See also
Goodwin MS et al (1971) J Autism Child Schizophrenia 1:48-62.

Coeliac disease may go undetected until lyphoma is discovered . It is
relevant that  one of the dominant symptoms  is depression (carried out in
Sweden) (eg Hallert C et al (1982) Scand J gastroenterol 17:25-28.)

2: Because we have a) isolated bovine casomorphin 1-8 immunoreactive peptides
from the urine and dialysis fluid of schizophrenics and autistics (eg
Reichelt KL et al (1991)Brain Dysfunction 4:308-319) and also find an
increased frequency  of IgA antibodies higher than the upper normal limit
(Reichelt et al (1994) Dev Brain Dysfunction 7:71-85; Reichelt and Landmark
(1994) Biol Psychiat In press), there is reason to believe that opioids from
the diet are important.The mucosa is normal in these cases as are endomycium
antibodies.

3: The structure of gliadinomorphin is Y-P-Q-P-Q-P-F and is found inside
Wieser s peptide causing coeliac disease. The structure of casomorphin
(bovine) is very similar : Y-P-F-P-G-P-I.  We have recently found evidence
for gliadinomorphin too (in prep).

4: Opioids may very well be important to the development of autism because
they modulate trophically CNS development ( Zagon and McLaughlin (1987) Brain
Res 412:68-72; Zagon and McLaughlin(1989)Brain Res 490:14-25).  Also the
psychophysiological work of Panksepp is extremely important  and relevant to
this  problem (eg Panksepp L et al (1980) neurosci Biobehav Rev 4:473-487).
The pruning of synapses which is essential to normal development is likewise
disturbed by opioids .

5. Certain epilepsies and CNS damage of various kinds can be related to
factors derived from gluten in spite of  normal vitamin levels .See for
instance Gobbi G et al (1992) The Lancet 340:439-443; Paul KD et al(1985) Z
Klin Med  40:707-709; Cooke WT et al (1966) Brain 89:683-722; Ward ME et al
(1985) Neurology 35:1199-1201; Kinney HC et al (1982) J neurol Sci
5:9-22;Finelli PF et al (1980)Neurology 30:245-249).

6.  The important genetic studies done by Sir M Rutter and his crew indicates
that at least two(2) genetic defects must be present. (Le Cotour A (1988)
Aspects of Autism .Edit:L Wing, gaskell ,The nat Aut Soc  pp 38-52). It is
therefore probable that either two peptidase defects ( Reichelt et al
(1994)Dev brain Dysfunct 7:71-85) or a peptidase defect combined with
sulphation defect as suggested by Prof Dr R Waring could be the root
cause.(Waring and Reichelt ; in press). After all defective transulphation
would cause defects in aminoglycans lining the gut wall and therefore
increase transmucosal transport or diffusion as shown in certain dieased
states ( Murch SH et al (1993) The Lancet 341:711-714). Certainly gut uptake
of various compounds should be performed as soon as possible in these
diseases.

7: Dr Sci MLG Gardner ,Univ of Bradford School of Biomed Sci is an authority
on the gut and various uptake mechanisms .His fax no is - 0274 309 742
England.

8.: In post-partum psychosis ,which is one of the most vivid psychotic
conditions known , the Swedes have shown that human casomorphin is the
mediator and accumulates in blood, spinal fluid and urine. (Lindstrom L et al
(1984)Am J Psychiat 141:1059-1066.) Human casomorphin is present as a family
of peptides and has the structure Y-P-F-V-E-P-I-P and exists as 1-8,1-7,1-6
etc.   It has long been known that stopping milk production fast (before
receptor changes take place) eleviates the psychotic condition .

9: There is going to be a very technical and basic meeting on the
relationship of gluten to disease especially epilepsy in San Marino (a small
independent country inside Italy)  april 10-12 1985. The registration  is in
the hands of:
San marino Conference c/o Ufficio Attivita promozionali
Instituto Sicurezza Sociale ,Via la Toscana -Cailungo
47031 Republica San Marino.

Cheers

Tiny

K. Reichelt
Pediatric Research Institute
N-0027 Oslo, Norway
Tel: +47 22 86 90 45
Fax: +47 22 86 91 17
E-mail: [log in to unmask]