<<Disclaimer: Verify this information before applying it to your situation.>>

Someone recently sent me a link about gut inflammations
and butyrate. The link below is mainly about Crohn's,
which a lot of celiacs also seem to have, but butyrate
seems to be helpful for easing inflammation in the gut
in general (and in preventing colon cancer), so all of us
with gut problems could benefit!

The nice thing is, you can get butyrate just by eating
more soluble fiber (an apple a day!). I believe it is also
found in fermented vegies (kraut and kimchi, for instance).
The fermented vegies might be good because they would
provide more butyrate higher up in the intestine, before
a lot of fermentation naturally takes place. You can
also buy butyrate supplements. And no I'm not connected
with anyone who sells supplements, fermented vegies, or
apples.


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Nutrition in Crohn Disease
from Current Opinion in Gastroenterology

Butyrate
Butyrate is a short-chain fatty acid produced by bacterial fermentation of dietary fiber and undigested starch in the colon. It is important in maintaining the health and integrity of colonic mucosa,[55] as it provides greater than 70% of the energy supply of the colonocyte.[56] Recently, it was demonstrated that butyrate inhibits the inflammatory response in CD by inhibiting the transcription factor nuclear factor kappa B (NF[]B) activation in immune cells.[57] NF[]B is involved in inflammatory and immune responses and regulates TNF. By inhibiting NF[]B, TNF is downregulated and, theoretically, inflammation will be reduced.

Already demonstrated in patients with steroid-resistant CD is marked improvement in those patients treated with monoclonal antibodies to TNF.[58] Although further studies are needed to determine the best method of administering butyrate, it offers promise for an immune modulatory therapy for treating patients with CD. Of note, an oral precursor of butyrate has recently been used in ulcerative colitis and was successful in lowering corticosteroid dose. Further utility in CD might be of special interest.


www.medscape.com/viewarticle/450317_8

(You may need to get an account with Medscape -- it is free. Click on the "butyrate" side link).

Heidi S

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