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To: [log in to unmask]
From: [log in to unmask] (Kalle Reichelt)
Date: 08/19/96 04:39:59 PM EDT
Subject: Downs syndrome
 
Hi.
I know nothing about the mechanisms causing the Fanconi syndrome.It is
correct that there is s slight increasein the frequency of coeliac disease
in Downs. More important though is the fact that without Downs syndrome
more than 1/3 of the children have extremely high IgA antibodies against
gliadin, gluten,lactoglobulin and casein as well as ovalbumin without
endomycium antibodies being increased.(1,2) There is an inverse
relationship size of the children and level of IgA to gliadin and gluten.
C P Reading in Australia thinks that there is a causal relationship Downs
because of the increase in antibodies found also by him (3).
Ref:
1:Kanavin \ et al (1988) Immunological studies of patients with Down's
syndrome. Acta med Scand. 224: 474-477.
2: Reichelt KL et al (1994) Increased levels of antibodies to food proteins
in Down Syndrome. Acta Paed japon 36: 489-492.
3:Reading CM (1984) Down's syndrome:Is Gluten/Alpha-gliadin
sensitivity/coeliac disease the cause? Int J Biosocial Res 6: 62-65.
 
All the best                                    Cheers
 
                                                        TINY
 
K. Reichelt
Pediatric Research Institute
N-0027 Oslo, Norway
Tel: +47 22 86 90 45
Fax: +47 22 86 91 17
E-mail: [log in to unmask]