<<Disclaimer: Verify this information before applying it to your situation.>>
 
As part of my defense in a thread in alt.support.arthritis Dr. Reichelt has
written another article for the Net. It is below. The rest of his Net
articles can be found at http://www.panix.com/~donwiss/reichelt.html (or I
can e-mail them out). In the newsgroup thread a fellow was saying that diet
has nothing to do with RA or depression, and had disparaged another of Dr.
Reichelt's articles. Don Wiss.
 
 
From:    [log in to unmask] (Kalle Reichelt)
Date:    26 Feb 1996
 
What most people ignore is that both peptides and trace amounts but
biologically significant amounts of proteins are taken up across the gut
mucosa(1,2). Because one molecule of gluten contains at least 15 opioid
sequences it is quite clear that this could cause a problem. Increased
peptide excretion is found in the urine of coeliacs before treatment (3)
(Reichelt et al in prep).
That this is so is confirmed by a series of papers that demonstrate intact
food proteins in mothers milk(4-7).
A Canadian group has confirmed that gluten does change a brain enzyme and
monoamine levels (8) in cats. They are not gluten eating animals.
There is increasing evidence that components from food do indeed cause
serious psychiatric(9-12) and neurological(13-16) disease. Even rheumatoid
arthritis as such may have a link to food proteins(17) and it well
established that stress (which such a disease is to a very large extent)
increases gut permeability. Nobody denies the possibility of reactive
depression, but there is little reason why this could not be made worse by
dietary factors. Because antibodies are indeed induced by peptides it may
even be so that dietary peptides by mimicry to endogenous cell surface
peptide sequences, may be responsible for many autoimmune diseases(18).
 
References:
1: Gardner MLG (1994) Physiology of the gastrointestinal tract. Edit: LR
Johnson. Raven press 3rd edit. pp 1795-1820.
2: Husby S et al (1985) Scand J Immunol 22:83-92.
3: Klosse JA et al (1972) Clin Chim Acta 42:409-422.
4: Kilshaw PJ and Cant AJ (1984) Inter. Arch Allergy Appl Immunol 75:8-15.
5: Axelsson I et al (1986) Acta paed Scand 75:702-707.
6: Stuart CA et al (1984) Clin Allergy 14:533-535.
7: Troncone R et al (1987) Acta paed Scand 76:453-456.
8: Thibault L et al (1988) J Clin Biochem Nutr. 4:209-221.
9: Hallert C et al (1982) Psychic disturbances in adult coeliac disease
III.Reduced central monoamine metabolism and signs of depression. Scand J
Gastroenterol 17:25-28.
10: Singh MM and Kay SR (1976) Wheat gluten as a pthogenic factor in
schizophrenia. Science 191:401-402.
11: Dohan FC and Grasberger JC (1973) relapsed schizophrenics: earlier
discharge from the hospital after cereal-free, milk-free diet. Amer J
Psychiat 130:685-686.
12: Reichelt KL et al (1990) The effect of gluten free diet on glycoprotein
attached urinary peptidee excretion and behaviour in schizophrenics. J
Orthomol Med 5:223-239.
13: Gobbi G et al (1992) Coeliac disease, epilepsy and cerebral
califications. The Lancet 340:439-443.
14: Paul K-D et al (1985) EEG-Befunde Zoeliakikranken Kindern in
Abh{ngigkkeit von der Ern{hrung. Z Klin Med 40:707-709.
15: Kahn A et al (1987) Difficulty of initiating sleep associated with cow's
milk allergy in infants. Sleep 10:116-121.
16: Hadjivassiliou M et al (1996) Does cryptic gluten sensitivity play a
part in neurological illness? The Lancet 347:369-371.
17: Kjeldsen-Kragh J et al (1991) Controlled trial of fasting and one-year
vegetarian diet in rheumatoid arthritis. The Lancet 338:899-902.
18: Karjalainen J et al (1992) Bovine albumin peptide as a possible trigger
of insulin-dependent diabetes mellitus. New Eng J Med 327:302-307.
 
All the best                            Cheers
 
                                                TINY
K. Reichelt
Pediatric Research Institute
N-0027 Oslo, Norway
Tel: +47 22 86 90 45
Fax: +47 22 86 91 17
E-mail: [log in to unmask]