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A new study identified a peptide which causes an immune reaction in a 
majority of active CD patients but no such reaction in any CD patients on 
a gluten-free diet.  Antibodies to this celiac peptide also recognize and 
bind to the rotavirus protein VP-7 and cause increased intestinal 
permeability.  Antibodies to VP-7 produced in rabbits also increase 
intestinal permeability.  The celiac peptide also binds to Toll-like 
receptor 4 and activates monocytes (white blood cells active in innate 
immunity.)  IgA and IgG antibodies to rotavirus protein VP-7 are present 
in a majority of CD patients and to a much lesser percent of the general 
population.  This suggests VP-7 may be involved in the pathogenesis of CD 
through a molecular mimicry mechanism.

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PLoS Medicine Volume 3, Issue 9, SEPTEMBER 2006 

In Celiac Disease, a Subset of Autoantibodies against Transglutaminase 
Binds Toll-Like Receptor 4 and Induces Activation of Monocytes
Giovanna Zanoni, Riccardo Navone, Claudio Lunardi, Giuseppe Tridente, 
Caterina Bason, Simona Sivori, Ruggero Beri, Marzia Dolcino, Enrico 
Valletta, Roberto Corrocher, Antonio Puccetti 

Editor's Summary (READ FIRST!)
< http://dx.doi.org/10.1371/journal.pmed.0030358#editor >

Full Text
< http://dx.doi.org/10.1371/journal.pmed.0030358 >

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