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>REQUEST FOR VOLUNTEERS IN CELIAC RESEARCH STUDY
>
>Dear Celiac Friends,
>
>As you may know, the Celiac Sprue Research Foundation will be initiating a
>short clinical trial to test whether gluten can be "detoxified"by enzyme
>treatment, thereby making it safe for Celiacs. If successful, this could
>pave the way for a celiac pill.
>
>For this trial we need adult celiac volunteers who are biopsy diagnosed.
>Details of the trial, including admission criteria, can be found below.
>
>I would be extremely grateful if you would consider participating in this
>study.  As of now we are significantly short on volunteers, and we must
>have a full list of potential participants by October 1, if the trial is to
>go forward.
>
>Over the past year the Greater Bay Area Celiac community has been at the
>vanguard in its support of the Celiac Sprue Research Foundation.  We deeply
>appreciate this support and recognize the continued commitment on your
>part.  I hope I can count on you one more time to volunteer for this trial.
>
>Please contact either Dr. Gail Pyle at 408-655-0384 (email:
>[log in to unmask])
>or Dr. Gary Gray at 650-327-1144 ([log in to unmask]) as soon as possible.
>
>Thank you very much,
>
>Chaitan Khosla
>President, Celiac Sprue Research Foundation
>   and Professor, Stanford University
>
>  P.O. Box 61193
>Palo Alto, CA 94306-1193
>Fax (650)-251-9865
>www.celiacsprue.org
>
>CELIAC SPRUE RESEARCH FOUNDATION STUDY BEGINS IN OCTOBER
>
>Investigators from the Celiac Sprue Research Foundation, a non-profit
>public charity, and the Palo Alto Medical Foundation, California are
>seeking 20
>volunteers who have Celiac Sprue to participate in a study called the
>"Gluten Detoxification Trial".  The Gluten Detoxification Trial will test
>the effects of consumption of an Orange Juice Mixture that has been
>modified by the addition of gluten pre-treated with an enzyme (PEP) that is
>intended to "detoxify" the gluten.  If the PEP is successful in detoxifying
>the gluten, then the stage will be set for development of a PEP therapeutic
>drug, or pill, that may allow Celiac Sprue patients to consume a regular
>gluten containing diet.
>
>The study involves 2 two-week stages,  separated by one month off.  The
>first stage will occur during the last two weeks in October.  The second
>stage will occur during the first two weeks in December.  Participants in
>this study will be randomized to consume an Orange Juice Mixture containing
>gluten daily for 14 days during one stage, and an Orange Juice Mixture
>containing gluten pre-treated with the PEP daily for 14 days during the
>other stage.  Participants will record symptoms daily during each stage,
>and will have laboratory tests measured before and after each stage.
>Participants will undergo a screening physical exam at the beginning of
>October, and brief follow-up exams after each stage at the Palo Alto
>Medical Foundation.
>
>Participants in the Gluten Detoxification Trial must meet all of the
>following criteria:
>
>1. Diagnosed with Celiac Sprue by small intestinal biopsy (participants
>must be able to provide a copy of the biopsy report).
>
>2. Have had at least one abnormal Celiac antibody test (e.g.
>transglutaminase (ttg), endomysial (EMA), anti-gliadin) in the past.
>
>3. Be in remission on a gluten-free diet.
>
>4. Be at least 18 years of age.
>
>Pre-registration is required to participate in the study.  If you can
>participate,
>please contact either Dr. Gail Pyle at 408-5-0384 (email:
>[log in to unmask])
>or Dr. Gary Gray at 650-327-1144 ([log in to unmask]) as soon as
>possible.
>Participants must be enrolled by October 1st.



>PARTICIPANTS MUST BE ABLE TO DRIVE TO THE PALO ALTO MEDICAL FOUNDATION,
>PALO ALTO, CALIFORNIA FOR BLOOD TESTING.



>THANK YOU VERY MUCH FOR GIVING THIS REQUEST CAREFUL CONSIDERATION.

* Please remember some posters may be WHEAT-FREE, but not GLUTEN-FREE *