<<Disclaimer: Verify this information before applying it to your situation.>> Here are some references to Dr. Fasano's research on gut permeability: http://brain.hastypastry.net/forums/showthread.php?p=243323 http://www.umm.edu/news/releases/diabetes_prevention.htm http://www.newswise.com/articles/view/510016/ The ALBA website has some great articles, a bit technical for the average reader but very interesting: http://www.albatherapeutics.com/ProductDevelopment/TherapeuticAreas/CeliacDisease/tabid/80/Default.aspx http://www.albatherapeutics.com/ProductDevelopment/TherapeuticAreas/IBD/tabid/82/Default.aspx Fasano's AT-1001 does not cure or heal leaky gut, nor does it address the reason for the body's over-production of zonulin. It is simply a dose-by-dose method of "closing the gates" for a limited amount of time (until another pill is taken), and initial trials seem to indicate that it does indeed work. Here are some very good articles explaining leaky gut theory: http://www.albatherapeutics.com/Vision/ScienceandTechnology/MucosalBiology/tabid/73/Default.aspx http://www.albatherapeutics.com/Vision/ScienceandTechnology/TightJunctions/tabid/74/Default.aspx http://www.albatherapeutics.com/Vision/ScienceandTechnology/Inflammation/tabid/75/Default.aspx http://www.albatherapeutics.com/Vision/ScienceandTechnology/Autoimmunity/tabid/76/Default.aspx Alba Therapeutics is currently developing a similar drug for asthma, (theory that in asthma the airways are "leaky") http://www.albatherapeutics.com/ProductDevelopment/TherapeuticAreas/Asthma/tabid/83/Default.aspx As in many autoimmune diseases including celiac disease, barrier function in asthma patients is compromised. Tight junctions of the epithelial cellular barrier in the lungs of asthma patients are leaky. This loss of barrier function allows antigens and environmental triggers to pass through the epithelial barrier and elicit a T-cell mediated autoimmune response in genetically susceptible individuals. Alba's approach to therapeutic intervention for asthma focuses on barrier function and the inhibition of increased paracellular permeability leading to the increased presentation of environmental stimuli and, ultimately, the inflammatory cascade. Janice in Alberta. [see earlier post below] > The topic of leaky gut was addressed this morning under the subject > "stomach > distress". > > The poster said, "as a celiac, most suffer from leaky gut syndrome. an > interesting pt of info is that leaky gut is also caused by other disease, > including arthritis. YOU MUST HEAL THE GUT...period, end discussion." > > The cause/effect is misplaced in that statement. > > - leaky gut is NOT caused by arthritis > - arthritis (and other auto-immune diseases) are triggered/caused by > having > a leaky gut. > > If you had a leaky gut before you got sick, that probably contributed to > your developing celiac diease, and/or other auto-immune diseases. Leaky > gut > can be caused by a number of things including but not limited to, > infections, pharmaceuticals and lifestyle choices. See Dr. Fasano's > research > with AT-1001 for more on this topic. > > Janice in Alberta. > * Send administrative questions to mailto:[log in to unmask] * Archives are at: Http://Listserv.icors.org/SCRIPTS/WA-ICORS.EXE?LIST=CELIAC
