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Subject:
From:
Hilary Shughart <[log in to unmask]>
Reply To:
Hilary Shughart <[log in to unmask]>
Date:
Tue, 11 Oct 2005 06:23:38 -0500
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<<Disclaimer: Verify this information before applying it to your situation.>>

Subject: False neg CD tests


False Negative Serological Results Increase with Less
Severe Villous Atrophy
       Dig Dis Sci. 2004 Apr;49(4):546-50
Celiac.com 08/27/2004 - Dr. Peter Green and colleagues at
the Department of Medicine, Columbia University College of
Physicians and Surgeons, New York, New York, conducted a
study designed to determine the sensitivity of the various
serological tests used to diagnose celiac disease. To do
this they looked at 115 adults with biopsy-proven celiac
disease who fulfilled strict criteria which included
serological testing at the time of their diagnosis, and a
positive response to a gluten-free diet. Out of those
studied, 71% had total villous atrophy, and 29% had
partial villous atrophy.

Serological results indicated that only 77% of those with
total and 33% of those with partial villous atrophy
actually tested positive for celiac disease, and it did
not matter whether the patients presented with classical
or silent symptoms. All patients who were positive for
anti-tissue transglutaminase had total villous atrophy.

The researchers conclude: "Seronegative celiac disease
occurs. Endomysial antibody positivity correlates with
more severe villous atrophy and not mode of presentation
of celiac disease. Serologic tests, in clinical practice,
lack the sensitivity reported in the literature."
from www.celiac.com Copyright © 1995-2004Scott Adams

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End of CELIAC Digest - 16 Jul 2005 to 17 Jul 2005 - Special issue (#2005-332)
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