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Subject:
From:
Rhonda Jared <[log in to unmask]>
Date:
Sat, 10 Mar 2001 14:49:39 -0500
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<<Disclaimer: Verify this information before applying it to your situation.>>

Thanks to all who responded to my question.  Responses were somewhat varied
as to whether gene HLA-DQ8 is as much an indicator or celiac as HLA-DQ2.  My
gene test results came back showing I have 2 copies of gene HLA-DQ8.
Didn't do the stool sensitivity test because I've been gluten free for 15
months.  Blood screens came back normal and no biopsy done because I wasn't
eating gluten, thanks to the CSA/USA website, for almost a month before
visiting the Dr.  Here are the responses I received.

1.  HLA-DQ2 gene is present in about 90% of diagnosed celiacs.  HLA-DQ8 is
the gene present in about 8 percent.

2.  According to a number of papers at the Baltimore conference, HLA-DQ2 is
the most important celiac gene, with HLA-DQ8 next most important.  Both DQ2
and DQ8 together account for only about half of celiac occurences, with
other genes unknown.   Genetics account for about 70% of celiac incidence
(My father could have been celiac). 30% of identical twins with one celiac
twin has a normal second twin.

3.  The genes are one and the same.

4.  A suggestion for another good site with knowledgeable people to answer
questions.   http://forums.delphi.com/celiac/messages

5.  (Enterolab - Dr. Fine):   DQ2 and DQ8 are different genes but both lead
to gluten sensitivity and celiac disease.   You are gluten sensitive and
need to be off gluten.  That is all you need to know.  It does not matter
what your intestine looks like under a microscope.  It makes you sick to eat
it.

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