<<Disclaimer: Verify this information before applying it to your situation.>>
The following cite and abstract from Medline is the most specific
description I've seen of the mechanism of "attack" on the celiac's GI tract
and of a mechanism of protection. Anyone know any mannan-rich food stuffs?
(Maybe Moses had the right idea. Had to get those Egyptian celiacs away
from that pernicious wheat agriculture in the Nile valley. ...just kidding-:)!!
John
FN- DIALOG(R)File 155:MEDLINE(R)|
CZ- (c) format only 1995 Knight-Ridder Info. All rts. reserv.|
AN- 07460940|
AN- <NLM> 90367940|
TI- Mannan and oligomers of N-acetylglucosamine protect intestinal mucosa
of celiac patients with active disease from in vitro toxicity of
gliadin peptides.|
AU- Auricchio S; De Ritis G; De Vincenzi M; Magazzu G; Maiuri L; Mancini E;
Minetti M; Sapora O; Silano V|
CS- Department of Pediatrics, II Faculty of Medicine, University of Naples,
Italy.|
JN- Gastroenterology; 99 (4) p973-8|
CP- UNITED STATES|
PY- Oct 1990|
SN- 0016-5085|
JC- FH3|
LA- ENGLISH|
DT- JOURNAL ARTICLE|
JA- 9012|
SF- AIM; INDEX MEDICUS|
AB- Wheat flour and other cereals toxic for celiac patients contain an
alcohol-soluble protein fraction that, under experimental conditions
simulating in vivo protein digestion, yields peptides that agglutinate
undifferentiated K 562(S) cells. In contrast, cereals well tolerated in
celiac disease (i.e., rice and maize) do not. Furthermore, purified
A-gliadin peptides that damage in vitro-cultured flat celiac mucosa are
powerful agglutinins for K 562(S) cells, whereas A-gliadin peptides
that do not show any adverse in vitro effect on celiac intestine lack
agglutinating activity. Mannan, acetylglucosamine, and its oligomers
(N,N'-diacetylchitobiose and N,N',N"-triacetylchitotriose) were able to
prevent and reverse cell agglutination induced by peptides from all the
toxic cereals. Moreover, mannan and N,N',N"-triacetylchitotriose
exhibited a protective effect on intestinal mucosa specimens of
patients with active celiac disease cultured with wheat protein-derived
peptides. These data are consistent with the hypothesis that the
agglutinating and toxic peptides are bound by carbohydrates.|
GS- Human; In Vitro|
DE- *Acetylglucosamine --Pharmacology --PD; *Celiac
Disease --Metabolism --ME; *Cereals --Toxicity --TO;
*Gliadin --Toxicity --TO; *Glucans --Pharmacology --PD;
*Glucosamine --Analogs and Derivatives --AA; *Intestinal
Mucosa --Drug Effects --DE; *Mannans --Pharmacology --PD; *Plant
Proteins --Toxicity --TO; *Trisaccharides --Pharmacology --PD;
Agglutination --Drug Effects --DE; Celiac Disease --Pathology --PA;
Child|
RN- 0 (Glucans); 0 (Mannans); 0 (Plant Proteins); 0
(Trisaccharides); 2706-64-1 (N,N-diacetylchitobiose); 3416-24-8
(Glucosamine); 38864-21-0 (N,N',N''-triacetylchitotriose); 7512-17-6
(Acetylglucosamine); 9007-90-3 (Gliadin)|
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