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Subject:
From:
John Dennis <[log in to unmask]>
Date:
Mon, 5 Jun 1995 04:23:47 -0400
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<<Disclaimer:  Verify this information before applying it to your situation.>>

The following cite and abstract from Medline is the most specific
description I've seen of the mechanism of "attack" on the celiac's GI tract
and of a mechanism of protection.  Anyone know any mannan-rich food stuffs?
(Maybe Moses had the right idea.  Had to get those Egyptian celiacs away
from that pernicious wheat agriculture in the Nile valley.  ...just kidding-:)!!

John


 FN- DIALOG(R)File 155:MEDLINE(R)|
CZ- (c) format only 1995 Knight-Ridder Info. All rts. reserv.|
AN- 07460940|
AN- <NLM> 90367940|
TI- Mannan and oligomers of N-acetylglucosamine protect intestinal mucosa
    of celiac patients with active disease from in vitro toxicity of
    gliadin peptides.|
AU- Auricchio S; De Ritis G; De Vincenzi M; Magazzu G; Maiuri L; Mancini E;
    Minetti M; Sapora O; Silano V|
CS- Department of Pediatrics, II Faculty of Medicine, University of Naples,
    Italy.|
JN- Gastroenterology; 99 (4) p973-8|
CP- UNITED STATES|
PY- Oct 1990|
SN- 0016-5085|
JC- FH3|
LA- ENGLISH|
DT- JOURNAL ARTICLE|
JA- 9012|
SF- AIM; INDEX MEDICUS|
AB- Wheat flour and other cereals toxic for celiac patients contain an
    alcohol-soluble protein fraction that, under experimental conditions
    simulating in vivo protein digestion, yields peptides that agglutinate
    undifferentiated K 562(S) cells. In contrast, cereals well tolerated in
    celiac disease (i.e., rice and maize) do not. Furthermore, purified
    A-gliadin peptides that damage in vitro-cultured flat celiac mucosa are
    powerful agglutinins for K 562(S) cells, whereas A-gliadin peptides
    that do not show any adverse in vitro effect on celiac intestine lack
    agglutinating activity. Mannan, acetylglucosamine, and its oligomers
    (N,N'-diacetylchitobiose and N,N',N"-triacetylchitotriose) were able to
    prevent and reverse cell agglutination induced by peptides from all the
    toxic cereals. Moreover, mannan and N,N',N"-triacetylchitotriose
    exhibited a protective effect on intestinal mucosa specimens of
    patients with active celiac disease cultured with wheat protein-derived
    peptides. These data are consistent with the hypothesis that the
    agglutinating and toxic peptides are bound by carbohydrates.|
GS- Human; In Vitro|
DE- *Acetylglucosamine --Pharmacology --PD;  *Celiac
    Disease --Metabolism --ME;  *Cereals --Toxicity --TO;
     *Gliadin --Toxicity --TO;  *Glucans --Pharmacology --PD;
     *Glucosamine --Analogs and Derivatives --AA;  *Intestinal
    Mucosa --Drug Effects --DE;  *Mannans --Pharmacology --PD;  *Plant
    Proteins --Toxicity --TO;  *Trisaccharides --Pharmacology --PD;
    Agglutination --Drug Effects --DE;  Celiac Disease --Pathology --PA;
     Child|
RN- 0   (Glucans); 0   (Mannans); 0   (Plant Proteins); 0
     (Trisaccharides); 2706-64-1   (N,N-diacetylchitobiose); 3416-24-8
     (Glucosamine); 38864-21-0   (N,N',N''-triacetylchitotriose); 7512-17-6
     (Acetylglucosamine); 9007-90-3   (Gliadin)|

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