2004 NIH Neuroscience Seminar Series
Monday, March 2 9, 2004,  Noon
Building 10, Lipsett Amphitheater
Dr. Story Landis, Director of the NINDS, invites you to attend Dr.
Chao's seminar:
MOSES CHAO, PH.D.,  New York University School of Medicine
"Unique Features of Neurotrophin Receptor Signaling"
The generation and differentiation of neurons and glial cells are
dependent upon cell-cell interactions mediated by a wide variety of
growth factors and cytokines. Dr. Chao's laboratory is interested in
receptor-mediated mechanisms that direct cell differentiation versus
cell proliferation in the nervous system. A major goal is to identify
the biochemical steps that provide specificity in NGF signaling. Control
of cell survival and death by neurotrophins is dictated by an unusual
transduction system consisting of two transmembrane receptors, the TrkA
tyrosine kinase and the p75 neurotrophin receptor, a member of the TNF
receptor superfamily. The structural and biochemical features of these
two receptors are being defined together with their intracellular
signaling mechanisms. (from
http://www.med.nyu.edu/research/chaom01.html)
Selected Publications:
Caporaso GL; Lim DA; Alvarez-Buylla A; Chao MV. "Telomerase activity in
the subventricular zone of adult mice". Molecular & cellular
neurosciences 2003 Aug;23(4):693-702
Chao, MV. "Neurotrophins and their receptors: A convergence point for
many signalling pathways". Nature reviews. Neuroscience (Online) 2003
APR;4(4):299-309
Chao MV. "Retrograde transport redux". Neuron 2003 Jul 3;39(1):1-2
Chao MV. "Neurotrophins and their receptors: a convergence point for
many signalling pathways". Nature reviews. Neuroscience 2003
Apr;4(4):299-309
Chao MV. "Dependence receptors: what is the mechanism?". Science's STKE
2003 Sep 16;2003(200):PE38
Jung KM; Tan S; Landman N; Petrova K; Murray S; Lewis R; Kim PK; Kim DS;
Ryu SH; Chao MV; Kim TW. "Regulated Intramembrane Proteolysis of the p75
Neurotrophin Receptor Modulates Its Association with the TrkA Receptor".
Journal of biological chemistry 2003 Oct 24;278(43):42161-9
Kim AH; Sasaki T; Chao MV. "JNK-interacting protein 1 promotes Akt1
activation". Journal of biological chemistry 2003 Aug 8;278(32):29830-6
For more information see our website -  http://neuroseries.info.nih.gov