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Subject:
From:
Meir Weiss <[log in to unmask]>
Reply To:
St. John's University Cerebral Palsy List
Date:
Thu, 20 May 2004 21:33:07 -0400
Content-Type:
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-----Original Message-----
From: NIH Neuroscience Seminar Series Announcements
[mailto:[log in to unmask]] On Behalf Of Wang, Gladys
(NIH/NINDS)
Sent: Thursday, May 20, 2004 20:08
To: [log in to unmask]
Subject: NIH Neuroscience Seminar Series Announcement


2004 NIH Neuroscience Seminar Series
Monday,  May 24, 2004,  Noon
Building 10, Lipsett Amphitheater

SALLY TEMPLE, PH.D.,  Albany Medical College

"Timing the Generation of Diverse Cell Types from CNS Stem Cells"

Dr. Temple is studying how embryonic neural progenitor cells generate
the numerous, diverse, cell types of the adult CNS. These studies may
lead to therapies for neurodegenerative disorders or for neural tumors.
Dr.Temple has designed a culture system in which single CNS progenitor
cells can divide and differentiate into clones of neurons and glial
cells. This led to the identification of different classes of progenitor
cells in embryonic forebrain, including one that may play a key role in
brain development: multipotential stem cells. Molecular mechanisms
regulating division and differentiation of brain progenitor cells will
be the focus of future studies.

Selected Publications:


Qian X, Goderie SK, Shen Q, Stern JH, Temple S Intrinsic programs of
patterned cell lineages in isolated vertebrate CNS ventricular zone
cells. Development 1998 Aug;125(16):3143-52

Shen Q, Qian X, Capela A, Temple S Stem cells in the embryonic cerebral
cortex: their role in histogenesis and patterning. J Neurobiol 1998
Aug;36(2):162-74

Qian X, Davis AA, Goderie SK, Temple S FGF2 concentration regulates the
generation of neurons and glia from multipotent cortical stem cells.
Neuron 1997 Jan;18(1):81-93

Davis AA, Temple S A self-renewing multipotential stem cell in embryonic
rat cerebral cortex. Nature 1994 Nov 17;372(6503):263-6

Temple S, Alvarez-Buylla A Stem cells in the adult mammalian central
nervous system. Curr Opin Neurobiol 1999 Feb;9(1):135-41

For more information see our website -
<http://neuroseries.info.nih.gov> http://neuroseries.info.nih.gov

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