From: NIH Neuroscience Seminar Series Announcements
[mailto:[log in to unmask]] On Behalf Of Wang, Gladys (NIH/NINDS)
[E]
Sent: December 29, 2010 16:34
To: [log in to unmask]
Subject: NIH Neuroscience Seminar Series: January 3, 2010
You are invited to attend the NIH Neuroscience Series lecture on Monday,
January 3, 2010 at noon in the Lipsett Amphitheater of the NIH Clinical
Center, 10 Center Drive, Bethesda, MD.
DAVID PERKEL, PH.D., Departments of Biology and Otolaryngology, University
of Washington, will present the seminar on "Basal ganglia mechanisms of
behavioral plasticity"
Vocal learning in songbirds is an experimentally accessible model system in
which to study the neural mechanisms of learning. Juvenile birds memorize
song(s) from an adult tutor and then use auditory feedback from their own
songs to compare with their memory of the tutor song(s). This comparison
guides a process of motor learning; through practice, juvenile birds
gradually learn to produce a highly stereotyped song that resembles the
tutor song. Extensive research has investigated the underlying neural
circuits that are involved in song learning and production. The Perkel lab
uses a variety of electrophysiological, anatomical and behavioral approaches
to probe the neural mechanisms that mediate song learning and song behavior.
Selected Publications:
Meitzen J, Weaver AL, Brenowitz EA, Perkel DJ (2009) Plastic and stable
electrophysiological properties of adult avian forebrain song-control
neurons across changing breeding conditions. J Neurosci. 29:6558-67.
Leblois A, Bodor AL, Person AL, Perkel DJ (2009) Millisecond timescale
disinhibition of thalamic neurons by relief of “just-in-time” basal ganglia
GABAergic veto, J. Neurosci.
Person AL, Gale S, Farries MA, Perkel DJ (2008) Organization of songbird
basal ganglia, including Area X, J. Comp. Neurol. 508:840-866.
Person AL, Perkel DJ (2007) Pallidal neuron activity increases during
sensory relay through thalamus in a songbird circuit essential for learning.
J. Neurosci. 27:8687-8698.
Meitzen J, Moore IT, Lent K, Brenowitz EA, Perkel DJ (2007) Steroid hormones
act transsynaptically within the forebrain to regulate neuronal phenotype
and song stereotypy, J. Neurosci. 27:12045-12057
Person AL, Perkel DJ (2005) Unitary IPSPs drive precise thalamic spiking in
a circuit required for learning. Neuron 26:129-140.
For more information see our website - http://neuroseries.info.nih.gov
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