Ken and Kat,
I also wonder what would have happened had the study used rat stem
cells rather than human stem cell implanted in rats. A woman I worked
with had a kidney transplant several years back, and later developed a
tumor in that kidney and ureter. I'm not saying for sure it was some
form of auto immune response, but I'd think the likelihood of an
autoimmune elated cancer developing would be higher when cros-species
transplantation is performed. I'm not advocating doing experimental
research on humans, but a check to see if tumors develop in rats with
Parkinson's who are given rat stem cells would seem logical.
Kendall
On 10/27/06, Kathleen Salkin <[log in to unmask]> wrote:
> The study was truly inconclusive as they killed the test animals
> before any tumors formed. So we don't know if the tumors would have
> been benign or malignant, or even if they would have formed. Also,
> would this have been the result of short-term treatment or long-
> term? Too many questions to be really conclusive.
>
> Kat
>
>
> On 27 Oct 2006, at 00:37, Kendall D. Corbett wrote:
>
> Ken,
>
> Is this the link you were talking about? If so, it does indicate an
> area where caution should be observed, but since there was improvement
> of the Parkinson's symptoms, I'd say it's too early to abandon the
> research entirely, especially since even in this study, the results
> seem to be inconclusive.
>
> Kendall
>
> http://today.reuters.com/news/articlenews.aspx?
> type=healthNews&storyID=2006-10-23T215819Z_01_TON379089_RTRUKOC_0_US-
> STEM-CELLS.xml&WTmodLoc=NewsArt-C2-NextArticle-1
>
> Stem cells might cause brain tumors, study finds
>
> WASHINGTON (Reuters) - Injecting human embryonic stem cells into the
> brains of Parkinson's disease patients may cause tumors to form, U.S.
> researchers reported on Sunday.
>
> Steven Goldman and colleagues at the University of Rochester Medical
> Center in New York said human stem cells injected into rat brains
> turned into cells that looked like early tumors.
>
> Writing in the journal Nature Medicine, the researchers said the
> transplants clearly helped the rats, but some of the cells started
> growing in a way that could eventually lead to a tumor.
>
> Various types of cell transplants are being tried to treat Parkinson's
> disease, caused when dopamine-releasing cells die in the brain.
>
> This key neurotransmitter, or message-carrying chemical, is involved
> in movement and Parkinson's patients suffer muscle dysfunction that
> can often lead to paralysis. Drugs can slow the process for a while
> but there is no cure.
>
> The idea behind brain cell transplants is to replace the dead cells.
> Stem cells are considered particularly promising as they can be
> directed to form the precise desired tissue and do not trigger an
> immune response.
>
> Goldman's team used human embryonic stem cells. Taken from days-old
> embryos, these cells can form any kind of cell in the body. This batch
> had been cultured in substances aimed at making them become brain
> cells.
>
> Previous groups have tried to coax stem cells into becoming
> dopamine-releasing cells.
>
> Goldman's team apparently succeeded and transplanted them into the
> rats with an equivalent of Parkinson's damage. The animals did get
> better.
>
> But the grafted cells started to show areas that no longer consisted
> of dopamine-releasing neurons, but of dividing cells that had the
> potential to give rise to tumors.
>
> The researchers killed the animals before they could know for sure,
> and said any experiments in humans would have to be done very
> cautiously.
>
> Scientists have long feared that human embryonic stem cells could turn
> into tumors, because of their pliability.
>
> Opponents of embryonic stem cell research cite such threats. Many
> opponents, including President George W. Bush and some members of
> Congress, believe it is immoral to destroy human embryos to obtain
> their stem cells.
>
>
> (c) Reuters 2006. All Rights Reserved.
>
>
>
>
>
> On 10/26/06, ken barber <[log in to unmask]> wrote:
> > in case you haven't heard one of the latest studies of
> > injecting stemcells into the brain show the propensity
> > of causing cancer and tumors. i wish i still had the
> > link.
> > we'll have to agree to disagree on mr. fox.
> >
> > --- "Kendall D. Corbett" <[log in to unmask]>
> > wrote:
> >
> > > Ken, since you've got your asbestos suit on, I
> > > don't see it as Fox
> > > "playing the pity card," as you put it. He's
> > > letting the public see
> > > the actual effects of the disease that he has. Stem
> > > cell research has
> > > the potential to more effectively treat, if not cure
> > > this condition.
> > > Since your Mom (and my uncle ) died from
> > > Parkinson's, and a good
> > > friend is very seriously disabled by it, my thought
> > > is that research
> > > should be continued, especially since halting stem
> > > cell research is
> > > not going to halt abortion. If a fetus is to be
> > > aborted anyway, which
> > > should always be the last option, what's so wrong
> > > with using some of
> > > the tissue that would otherwise be destroyed to
> > > improve the lives of
> > > others?
> > > Kendall
> > >
> > > On 10/25/06, ken barber <[log in to unmask]> wrote:
> > > > well, kat he has admitted to not taking his meds
> > > when > he makes public appearances that is to
> > > emphasise the > disease. he wrote it in his book.
> > > >
> > > > as much as this group does not like the "pitiful"
> > > card played, i can not be >symathetic to the man
> > > playing the "pitiful card" in a polictical ad.
> > > >
> > > > rush limbaugh may be brash, caustic, and blunt,
> > > but he
> > > > is no idiot.
> > > >
> > > > i saw the ad and in my opinion, mr fox was off his
> > > > meds as he admits to doing at times. imho playing
> > > the
> > > > "pitiful card." i resent it as my mom died with
> > > > parkingson's disease.
> > > >
> > > > go ahead, i have my asbestos suit on.
> > > >
> > > > --- Kathleen Salkin <[log in to unmask]> wrote:
> > > >
> > > > > Are you serious or do you have your tongue in
> > > your
> > > > > cheek? I happen
> > > > > to sympathise with Michael J. Fox and think Rush
> > > > > Limbaugh is a
> > > > > blithering idiot.
> > > > >
> > > > > Kat
> > > > >
> > > > >
> > > > > On 25 Oct 2006, at 14:45, Mike Collis wrote:
> > > > >
> > > > > Ken, what was Rush Limbaugh thinking when he
> > > > > criticized Michael J.
> > > > > Fox? "He
> > > > > is exaggerating the effects of the disease.
> > > He's
> > > > > moving all around and
> > > > > shaking and it's purely an act. . . . This is
> > > really
> > > > > shameless of
> > > > > Michael J.
> > > > > Fox. Either he didn't take his medication or
> > > he's
> > > > > acting."
> > > > >
> > > > > Shades of T4! What's next? Maybe you are
> > > acting
> > > > > like you have c.p?
> > > > >
> > > > > -----Original Message-----
> > > > > From: Cerebral Palsy List
> > > > > [mailto:[log in to unmask]] On
> > > > > Behalf Of
> > > > > ken barber
> > > > > Sent: Tuesday, October 24, 2006 10:13 PM
> > > > > To: [log in to unmask]
> > > > > Subject: Re: Interesting WashPost Article.
> > > > >
> > > > > it is no doubt a tough year for the GOP.
> > > > >
> > > > > --- Kendall David Corbett <[log in to unmask]>
> > > wrote:
> > > > >
> > > > > > A similar story is unfolding in Wyoming....
> > > > > >
> > > > > >
> > > > > >
> > > > > >
> > > > >
> > > >
> > >
> > http://www.washingtonpost.com/wp-dyn/content/article/2006/10/23/
> > AR200610
> > > > > > 2301174.html
> > > > > >
> > > > > >
> > > > > >
> > > > > >
> > > > > >
> > > > > > Kendall
> > > > > >
> > > > > >
> > > > > >
> > > > > > An unreasonable man (but my wife says that's
> > > > > > redundant!)
> > > > > >
> > > > > >
> > > > > >
> > > > > > The reasonable man adapts himself to the
> > > world;
> > > > > the
> > > > > > unreasonable one
> > > > > > persists in trying to adapt the world to
> > > himself.
> > > > > > Therefore, all
> > > > > > progress depends on the unreasonable man.
> > > > > >
> > > > > >
> > > > > >
> > > > > > -George Bernard Shaw 1856-1950
> > > > > >
> > > > > >
> > > > > >
> > > > > >
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