http://www.forward.com/articles/israel-leads-the-way-on-stem-cells/
Israel Leads the Way on Stem Cells
How the Jewish state became the world's stem-cell capital
Joshua Yaffa | Fri. August 25, 2006
For people who suffer from familial dysautonomia (FD), hope recently came in the
form of an Israeli chicken egg.
In 2001, a team led by Bar-Ilan University professor Ron Goldstein implanted
human embryonic stem cells into chicken embryos to study the early stages of
normal cellular development.
Now, Goldstein is using embryonic stem cells to create FD-carrying human nerve
cells in an attempt to better understand how the degenerative genetic disease
works and to test possible treatments.
"Once we can produce FD-infected nerve tissue in a petri dish, we will have a
model to understand what is happening on a molecular level," Goldstein told the
Forward. "And this model could also be used to test new drug therapies for the
disease."
Familial dysautonomia is a degenerative disease of the peripheral nervous system
- the nerves and neurons outside the central nervous system - that is found
exclusively among Ashkenazic Jews. People who suffer from dysautonomia have
difficulty swallowing and regulating such involuntary responses as body
temperature and blood pressure.
Embryonic stem cells are particularly useful for advanced FD research, because
of their pluripotent nature, which means they can proliferate indefinitely and
develop into virtually any cell type. Essentially they are a "blank slate,"
Goldstein said. These unique traits also make stem cells an attractive resource
for medical researchers studying other, more common degenerative diseases such
as Alzheimer's and Parkinson's.
But because days-old human embryos are destroyed in this process, various
religious and pro-life groups have opposed the research. In July, President Bush
vetoed a bill designed to award federal funding for embryonic stem-cell
research.
Unlike some branches of Christianity, Judaism places no theological restrictions
on research work with embryonic stem cells. While experimental work has slowed
in the United States, scientists such as Goldstein have flourished in Israel in
recent years.
"According to how Jewish tradition understands the fetus in utero, until the
40th day it is 'like water,'" explained Rabbi Elliot Dorff, professor at the
University of Judaism and author of "Stem Cell Research," a rabbinic edict
approved by The United Synagogue of Conservative Judaism. From the 41st day
onward, Jewish tradition considers a fetus "like the thigh of its mother," and
therefore a full human being. Stem cells are harvested from embryos within 14
days of gestation, so there is no theological prohibition against their medical
use according to the Conservative movement.
"The Jewish religion would consider it far better to use [embryonic stem cells]
for cures than to simply throw them away," Dorff said, citing the talmudic
concept of saving a life in jeopardy, pikuach nefesh.
A wide range of Jewish organizations, including Hadassah, the Orthodox Union and
B'nai B'rith International have pushed for increased domestic funding for
stem-cell research. The chief officer of medical ethics at the Israeli Health
Ministry, Rabbi Mordechai Halperin, said everyone agrees that using stem cells
to research potential medical cures is permissible. "If Jews have ever been in
complete agreement on anything, then this issue is it," Dorff said.
With no religious or legal restrictions on using stem cells for scientific
purposes, Israel has emerged as a leading center. According to a recent study
published in the magazine The Scientist, Israeli researchers, per capita, are
the world's most prolific authors of articles in scientific journals on stem
cells. The United States is number six on the list. State research centers such
as Jerusalem's Hadassah Medical Center and Haifa's Rambam Medical Center have
emerged as global leaders in advanced stem- cell research.
"The big difference is, here you can get governmental money," Goldstein said,
noting that the National Institutes of Health would not have approved funding
for his earlier stem-cell experiments.
Medical advocacy groups in the United States, like the New York-based Familial
Dysautonomia Foundation, are acutely aware of both the promise of Goldstein's
research and the difficulty in supporting such work domestically. "The best work
we could have done was in Israel," said David Brenner, president of the FD
Foundation. The foundation gave Goldstein a $200,000 grant.
"U.S. labs couldn't take our money for work on embryonic stem cells if they also
receive money from the government," Brenner said.
To circumvent these restrictions, however, private groups such as the $100
million Harvard Stem Cell Institute are forming to create an alternative funding
stream for stem-cell projects in the United States.
"We [Israelis] had a little bit of head start," Goldstein acknowledged, but "I
think more and more we will lose our edge."
Goldstein cautioned that more advanced treatments - like using stem cells to
grow functioning nerve cells to replace those that did not develop properly in
FD patients - are not yet on the medical horizon. "People may think that stem-
cell replacement therapy is right around the corner, but it's not," Goldstein
said. "It may not be five or even 10 years away."
But Goldstein does hope that his six-person team will have the ability to test
human neurons with FD within the next couple of years. "Mostly the issue is
raising funds," he said, echoing a common sentiment in the stem-cell research
community.
Dorff, who authored the book "Matters of Life and Death: A Jewish Approach to
Modern Medical Ethics," suggested that it is no accident Israelis have emerged
at the forefront of stem-cell research.
"Judaism is unique among the religions of the world in the emphasis it places on
medical research," he said. "Our theology portrays the doctor as the partner and
agent of God in the ongoing act of healing."
Fri. August 25, 2006
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