Dear List,

I found this on medline at http://www.ncbi.nlm.nih.gov:80/entrez/query.

Does anyone know what SIR to S-100 protein is?

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Yonsei Med J 2000 Jun;41(3):328-32


Serum immunoreactivity to S-100 in children with cerebral palsy and delayed
development and in their healthy parents.

Park ES, Park CI, Baek SY, Kim SW, Baek SK, Kim HO

Department of Rehabilitation Medicine, Yonsei University College of
Medicine, Seoul, Korea.

The passive immunization of pregnant female rats to S-100 protein often
leads to ultra-structural abnormalities in the brain glial structures of
the offspring of these rats and induces signs of delayed development in the
fetal brain. Additionally passive immunization of pregnant animals with
certain antigens induces permanent Ag-specific changes in the immune
response of their offspring. The purpose of this study was to investigate
serum immunoreactiviy (SIR) to S-100 in cerebral-palsied and
developmentally-delayed children as well as in their healthy parents and to
evaluate its significance related to radiologic findings of brain MRI and
single photon emission computed tomography (SPECT). The subjects were
children with cerebral palsy and delayed development that had abnormal
findings on brain MRI or Brain SPECT. SIR to S-100 protein was measured by
ELISA method in the patients, their healthy parents, 20 normal adult
controls and 22 normally developed children. The SIR to S-100 protein was
significantly higher in the cerebral-palsied and developmentally-delayed
children when compared to that of the normal control group children.
Increased SIRs were detected in healthy mothers but not in their fathers.
There was no difference of SIR between the cerebral-palsied and
developmentally-delayed children or any significant difference of SIRs
according to the findings of the brain MRI or to developmental quotients.
But, the SIRs to S-100 protein were higher in the group of more abnormal
findings on brain SPECT.

PMID: 10957886, UI: 20413725



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