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Date: | Fri, 6 Aug 1999 14:35:53 -0400 |
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Thought you all might find this recent paper interesting:
TITLE: Prevalence and early diagnosis of coeliac disease in
autoimmune thyroid disorders [In Process Citation]
AUTHORS: Cuoco L; Certo M; Jorizzo RA; De Vitis I; Tursi A; Papa A;
De Marinis L; Fedeli P; Fedeli G; Gasbarrini G
AUTHOR AFFILIATION: Department of Internal Medicine, Catholic University S.C.,
Rome, Italy.
SOURCE: Ital J Gastroenterol Hepatol 1999 May;31(4):283-7 [MEDLINE
record in process]
CITATION IDS: Pmid: 10425571 Ui: 99354303
ABSTRACT: BACKGROUND AND AIMS: Coeliac disease is associated with
several autoimmune disorders such as insulin-dependent
diabetes, Sjogren's syndrome, Addison's disease and thyroid
diseases. The aim of our study was to evaluate the
prevalence of coeliac disease in patients affected by
autoimmune thyroid diseases by means of anti-gliadin and
anti-endomysial antibodies.
PATIENTS: We studied 92 patients affected by autoimmune
thyroid diseases (47 chronic autoimmune thyroiditis, 22
Hashimoto's thyroiditis and 23 Graves' disease). Ninety
patients with non autoimmune thyroid disorders (51
multifollicular goitre, 28 solitary nodule and 11 papillary
carcinoma) and 236 blood donors also took part in the study
as control groups. METHODS: Total serum IgA were measured
in all subjects to exclude selective IgA deficiency; then
we measured anti-gliadin antibodies and anti-endomysial
antibodies. In patients with anti-gliadin/anti-endomysial
antibody positivity and/or with haematinic and laboratory
signs of malabsorption we carried out gastrointestinal
endoscopy with duodenal histological examination.
RESULTS: Among the 92 patients with autoimmune thyroid
disease, 4 (4.3%) showed anti-gliadin and anti-endomysial
positivity and had coeliac disease; among the 90 patients
with non autoimmune thyroid diseases, 1 (1.1%) had coeliac
disease; finally, among the blood donors, 1 subject (0.4%)
was anti-gliadin-anti-endomysium antibody positive and had
coeliac disease. Those subjects presenting with only anti-
gliadin antibody positivity did not have coeliac disease.
CONCLUSIONS: These results show that the prevalence of
coeliac disease in patients with autoimmune thyroid
diseases is significantly increased when compared with the
general population (p = 0.009) but not with patients
affected by non autoimmune thyroid disorders (p = 0.18).
We suggest a serological screening for coeliac disease in
all patients with autoimmune thyroid disease measuring
anti-endomysial antibodies, considering that early
detection and treatment of coeliac disease are effective
in preventing its complications.
Mary Thorpe/Mutschler lab
Dept. of Plant Breeding
Cornell University
Ithaca, NY 14850
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