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Paleolithic Eating Support List <[log in to unmask]>
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Thu, 17 Jun 1999 02:11:07 -0700
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Found this citation of a study on message board... thoughts?

<<Albert Meier, professor of zoology at Louisiana State University,
initiated a study of bromocriptine after 25 years of research on
animals' body rhythm biology during migration and hibernation. What he
attempted to translate to humans was the finding that many animals
reduce or increase their body fat without altering food intake or
activity levels. (Insight, Mar 26 1990)

Meier, Cincotta and Lovell have dramatically reduced body fat with
bromocriptine taken orally at times calculated to reset circadian
hormone rhythms to phase relationships that cause loss of body fat.
Bromocriptine is a dopamine agonist used to suppress lactation and in
treatment of Parkinson's disease.

"The phase of the prolactin rhythm differs in lean and fat sparrows,
fish, rats, and humans. Daily injections of prolactin in animals at
times when the daily peaks occur in the plasma of lean and fat animals
produce the appropriate decrease or increase in fat stores within two
weeks."

In early clinical trials, without food restriction, body fat was
reduced equivalent to a 420 calorie VLCD, but without the loss of lean
body mass caused by weight loss diets. Studies with Syrian hamsters
investigating whole body protein turnover indicate this treatment
enhances protein synthesis, redirecting anabolic activities from lipid
to protein. Apparently the timed bromocriptine treatment alters the
genetically controlled partitioning of nutrients described in "The
response to long-term overfeeding in identical twins" discussed above.

In the second study reported in Experientia 48 (March 1992 p. 248-), 15
diabetic subjects were given timed bromocriptine treatment. As with the
non-diabetic subjects, all 15 diabetic subjects lost fat >>


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