Subject: Re: šP-F Body temperature,
enzymes and obesity (was:
Protein Insulin
Ilya wrote:
>Amadeus Schmidt wrote:
>> Excess calories can't be just discarded by
the body,
>> they *have* to be stored or used.
>Nope, they can and are routinely discarded by
the body.
>After all that's what ketostix (urine test
strips) measure -
>ketones in urine (which are a perfectly good
source of energy,
>but in excess, which the body gets rid of in
urine). They
>can also be gotten rid of in breath and I
believe sweat.
True, exhaled or urinated ketones are one
exception of
the above general Rule.
Still it appears to me, that the purpose that
kestone bodies are
produced for, is *not* to discard some excess
kalories.
(to the opposite, animals or humans eating
animal bodies are in
trouble to aquire enough calories and have to
convert protein for).
Ketone bodies seem to be a by-product of
energy acquisition
from fatty acids, and therefore constitute a
(small) energy loss
in this pathway.
I've read at the site:
http://medtstgo.ucdavis.edu/endo/lecture/metli
pid.htm
>... Ketone bodies... A third ketone body,
acetone, is
>produced by non-enzymatic decarboxylation of
acetoacetate.
> Ketone body formation occurs exclusively in
liver and,
>although prominent in both starvation and
diabetes,
>it is not known to be under direct hormonal
control.
>It appears to occur
>predominantly because of the high rate of
delivery of fatty acids couple
>with the removal of oxaloacetate for
gluconeogenesis.
>All three ketone bodies, acetoacetate,
ß-hydroxybutyrate and acetone,
>readily exit the liver into the systemic
blood.
>The body is unable to metabolize acetone,
>and it is eliminated in the urine and exhaled
by the lungs.
I think ketone bodies are a small hope if
someone is trying to
loose excess kalories.
The focus on energy balance should be, IMHO in
our
intrinsic hunger/appetite regulation.
As for example described at:
http://medtstgo.ucdavis.edu/endo/lecture/metap
pet.htm
>....Most humans, once they
>have physiologically matured, maintain quite
a stable body weight.
>As with body temperature, there appears to be
a set point for weight
>in each individual. If, as illustrated ...,
an adult purposely fasts,
>body weight will decrease. Upon refeeding,
there will initially be a
>greater intake of food as the body returns to
the original set point
>of body weight.
My guess is, that that "set point" is most
often determined by the
availability of one or few essential
micronutrients in food.
regards
Amadeu
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