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| Date: | Sat, 28 Mar 1998 14:00:10 +0600 |
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<<Disclaimer: Verify this information before applying it to your situation.>>
Dear List members,
This is doctor Michail Valivach again, the one who performed investigations
in the celiacs participants of the list (QUESTIONS). I have received
37 replies and 32 of them were selected for statistical analysis. I enclose
the results. May be it will be interesting for the List members to compare
themselves with an "average celiac".
I compose a computer expert system for practical purposes. Thanks to
the responders it became possible to make a screening program to search for
the patients who need to be tested for CD.
The only difficulty I have today is absence of control group. The region
we live in is ecologically unfavorable (radiation, mercury, lead) and our
residents can not be used as a control group. I want to ask List members
aged above 25 to answer my QUESTIONS. It is necessary for participants to have
no serious diseases. I will make comparative analysis and report you the
results. The QUESTION are sent again in a separate message.
Thanks for everybody for collaboration.
I am sorry for my bad English.
Michail Valivach, MD, Pavlodar, Kazakhstan
-------------------------------------------------------------
Common characteristics of the celiac group
(Note: only the signs with frequency above 30% are listed)
SEX
G1: 32 N1 í1 +/- m1 %
MALES 32 28.1 8.1
FEMALES 32 71.9 8.1
LIFE PERIOD
G1: 32 N1 í1 +/- m1 %
PUBERT. 32 6.2 4.3
FERTIL. 32 53.1 9.0
POSTFERTIL. 32 40.6 8.8
BODY WEIGHT
G1: 32 N1 í1 +/- m1%
SIGNIFICANTLY BELOW NORMAL 32 3.1 3.1
BELOW NORMAL 32 9.4 5.2
NORMAL 32 68.8 8.3
ABOVE NORMAL 32 12.5 5.9
SIGNIFICANTLY ABOVE NORMAL 32 6.2 4.3
MEAN AGE 32 46.446 2.338
MEAN HEIGHT in cm 32 157.219 7.423
MEAN WEIGHT in kg 32 62.031 3.814
GENERAL CONDITION
G1: 32 N1 í1 +/- m1 %
Fatigue 30 0.567 9.2
Frequent or chronic infections 32 0.344 8.5
THE SKIN
Lip dryness 32 75.0 7.8
Rough skin of hands 32 75.0 7.8
Skin Dryness 27 66.7 9.2
Itching 32 65.6 8.5
Nail fragility 32 62.5 8.7
Predisposition to acne 30 56.7 9.2
Bad tolerance to sun burns 30 50.0 9.3
Dry elbows 31 45.2 9.1
Hair dryness 31 41.9 9.0
Scaling or roughness around the
eyes or above the brows 31 41.9 9.0
Scaling dermatitis 31 41.9 9.0
Nail wall fragility 30 36.7 8.9
Dandruff 31 35.5 8.7
MUCOUS MEMBRANES
Cracks on the tongue 31 35.5 8.7
Dryness of the mucous membranes 31 45.2 9.1
Gum bleeding after tooth brushing 29 37.9 9.2
DIGESTIVE SYSTEM
Hemorrhoids 32 56.2 8.9
Visible steatorrhea 31 54.8 9.1
Intestinal murmur after food 29 48.3 9.4
Feeling bloated after food 31 45.2 9.1
Rotten smell of stool 29 41.4 9.3
Epigastric pains 29 37.9 9.2
Intestinal murmur after milk 28 35.7 9.2
Gastric pains or nausea on fasting 31 35.5 8.7
Unpleasant smell from the mouth 32 34.4 8.5
Heartburn or regurgitation 30 33.3 8.8
Frequent urges to defecate 30 33.3 8.8
Liquid or semiliquid stool 31 32.3 8.5
Pains below the left ribs 29 31.0 8.7
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NOTE:
In the tables below correlations of different signs with each other
are given. The signs which did not reach statistical significance were
omitted.
List of the Tables:
Age groups
Acne in CD
Predisposition to allergic reaction in CD
Feeling bloated after food in CD
Skin dryness and/or irritation around the eyes and/or above
the brows in CD
Scaling and/or dryness of the cheeks in CD
Skin dryness and/or irritation around the eyes and/or above
the brows in CD
Scaling and/or dryness of the cheeks in CD
Fragmented stool in CD
Predisposition to spastic constipation in CD
Hemorrhoids in CD
Predisposition to atonic constipation in CD
Scaling dermatites in CD
Dry elbows in CD
Epigastric pains in CD
Epigastric pains or nausea on fasting in CD
Fatigue in CD
Hand dryness, and/or scaling and/or irritation in CD
Predisposition to hairloss in CD
Predisposition to frequent or chronic infections in CD
Skin itching in CD
Lip dryness in CD
Intestinal murmur after food in CD
Nail fragility in CD
Skin irritation in the nasolabial region in CD
Scaling of the nose in CD
Patch-shaped foci of hyperkeratosis in CD
Stool with rotten smell in CD
Liquid or semiliquid stool in CD
General skin dryness in CD
Bad tolerance to sunburns in CD
Visible steatorrhea in CD
Frequent urges to defecate in CD
------------------------------------------------------------------
Age groups
Age < 46 Age > 46
G1: 14 G2: 17 N1 í1 +/- m1 N2 í2 +/- m2 %
Acne 14 78.6 11.4 15 33.3 12.6 P<0.01
Itching 14 42.9 13.7 17 82.4 9.5 P<0.05
Gum bleeding after
tooth brushing 12 66.7 14.2 16 18.8 10.1 P<0.01
Heartburn or
regurgitation 13 15.4 10.4 16 50.0 12.9 P<0.05
Feeling bloated
after food 14 14.3 9.7 16 68.8 12.0 P<0.01
Intestinal murmur
after food 14 28.6 12.5 14 71.4 12.5 P<0.05
Hemorrhoids 14 35.7 13.3 17 70.6 11.4 P<0.05
Undigested food
in feces 13 38.5 14.0 15 6.7 6.7 P<0.05
---------------------------------------------------------------------
Acne in CD
Celiacs with acne C without acne
N1 í1 +/- m1 N2 í2 +/- m2
Acne 16 100.0 0.0 13 0.0 0.0
Irritation or brown
cover of the tongue 16 31.2 12.0 12 0.0 0.0 P<0.05
Gum bleeding after
tooth brushing 15 60.0 13.1 12 16.7 11.2 P<0.05
Undigested food
in feces 15 40.0 13.1 13 00.0 00.0 P<0.01
---------------------------------------------------------------
Predisposition to allergic reaction in CD
Predisposed to Not predisposed
allergy to allergy
G1: 21 G2: 8 N1 í1 +/- m1% N2 í2 +/- m2%
AGE 21 49.926 2.024 8 38.795 6.709 P<0.05
Frequent or chronic
infections 21 47.6 11.2 8 0.0 0.0 P<0.01
Lip dryness 21 85.7 7.8 8 50.0 18.9 P<0.05
Skin dryness 17 82.4 9.5 8 37.5 18.3 P<0.05
Scaling dermatitis 20 55.0 11.4 8 12.5 12.5 P<0.05
Rough skin of hands 21 85.7 7.8 8 50.0 18.9 P<0.05
Itching 21 81.0 8.8 8 25.0 16.4 P<0.01
Dryness of the mucous
membranes 20 55.0 11.4 8 12.5 12.5 P<0.05
Unpleasant smell
from the mouth 21 38.1 10.9 8 0.0 0.0 P<0.05
Epigastric pains 21 38.1 11.8 8 0.0 0.0 P<0.01
Feeling bloated
after food 21 61.9 10.9 8 12.5 12.5 P<0.05
Gastric pains or
nausea on fasting 21 47.6 11.2 8 0.0 0.0 P<0.01
Unpleasant sensation on the right
below the ribs 20 40.0 11.2 8 0.0 0.0 P<0.05
Intestinal murmur
after food 19 68.4 11.0 8 12.5 12.5 P<0.01
Frequent urges to
defecate 20 50.0 11.5 8 0.0 0.0 P<0.01
Predisposition to
allergic reactions 21 100.0 0.0 8 0.0 0.0
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Feeling bloated after food in CD
have the feeling have not the feeling
G1: 14 G2: 17 N1 í1 +/- m1 N2 í2 +/- m2
Early turning
gray 14 35.7 13.3 17 5.9 5.9 P<0.05
Lip cyanosis 11 27.3 14.1 16 0.0 0.0 P<0.05
Cyanotic marbled
skin 12 33.3 14.2 16 0.0 0.0 P<0.01
Itching 14 92.9 7.1 17 41.2 12.3 P<0.01
Epigastric pains 13 61.5 14.0 16 18.8 10.1 P<0.05
Heartburns or belch 14 57.1 13.7 16 12.5 8.5 P<0.01
Feeling bloated
after food 14 100.0 0.0 17 0.0 0.0
Predisposition to
allergic reactions 14 92.9 7.1 15 53.3 13.3 P<0.05
-----------------------------------------------------------------------
Skin dryness and/or irritation around the eyes and/or above
the brows in CD
G1: 13 G2: 18 N1 í1 +/- m1 N2 í2 +/- m2
Nail wall fragility 13 61.5 14.0 16 18.8 10.1 P<0.05
Skin roughness in the
nasolabial region 13 61.5 14.0 14 0.0 0.0 P<0.01
Scaling or roughness
around the eyes or
above the brows 13 100.0 0.0 18 0.0 0.0
Scaling and/or dryness
of the cheeks 13 46.2 14.4 18 5.6 5.6 P<0.01
Changed skin on
the ears 12 41.7 14.9 18 0.0 0.0 P<0.01
Skin dryness 11 100.0 0.0 15 46.7 13.3 P<0.01
Follicular
hyperkeratosis 8 50.0 18.9 12 0.0 0.0 P<0.01
Hand dryness 13 92.3 7.7 18 61.1 11.8 P<0.05
Itching 13 84.6 10.4 18 50.0 12.1 P<0.05
Foot cyanosis 11 27.3 14.1 14 00.0 00.0 P<0.05
Frequent urges to
defecate 13 53.8 14.4 16 18.8 10.1 P<0.05
Visible steatorrhea 13 76.9 12.2 17 41.2 12.3 P<0.05
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Scaling and/or dryness of the cheeks in CD
Have Not have
G1: 7 G2: 25 N1 í1 +/- m1 N2 í2 +/- m2
Nail wall fragility 7 71.4 18.4 23 26.1 9.4 P<0.05
Lip cyanosis 6 33.3 21.1 21 4.8 4.8 P<0.05
Skin roughness in the
nasolabial region 7 71.4 18.4 21 14.3 7.8 P<0.01
Scaling or roughness
around the eyes or
above the brows 7 85.7 14.3 24 29.2 9.5 P<0.01
Dryness of the cheeks 7 100.0 0.0 25 0.0 0.0
Scaling and/or dryness
of the nose 7 57.1 20.2 24 12.5 6.9 P<0.01
Changed skin on
the ears 7 42.9 20.2 24 8.3 5.8 P<0.05
Skin dryness 6 100.0 0.0 21 57.1 11.1 P<0.05
Itching 7 100.0 0.0 25 56.0 10.1 P<0.05
Foot cyanosis 7 42.9 20.2 19 0.0 0.0 P<0.01
"Smooth tongue" 7 42.9 20.2 23 8.7 6.0 P<0.05
Dryness of the mucous
membranes 7 85.7 14.3 24 33.3 9.8 P<0.01
Gum bleeding after
tooth brushing 7 71.4 18.4 22 27.3 9.7 P<0.05
Epigastric pains 5 100.0 0.0 24 25.0 9.0 P<0.01
Heartburn or belch 7 71.4 18.4 23 21.7 8.8 P<0.01
Gastric pains or
nausea on fasting 7 85.7 14.3 24 20.8 8.5 P<0.01
Frequent urges to
defecate 7 85.7 14.3 23 17.4 8.1 P<0.01
Undigested food in
feces 6 50.0 22.4 23 13.0 7.2 P<0.05
Predisposed to
allergy 6 100.0 0.0 23 56.5 10.6 P<0.05
Predisposed to long
lasting fever 6 16.7 16.7 22 0.0 0.0 P<0.05
------------------------------------------------------------------------
Fragmented stool in CD
Have Have not
G1: 7 G2: 20 N1 í1 +/- m1 N2 í2 +/- m2
Fatigue 6 100.0 0.0 20 45.0 11.4 P<0.01
Skin dryness 7 100.0 0.0 17 58.8 12.3 P<0.05
Cracks on the tongue 7 71.4 18.4 20 25.0 9.9 P<0.05
Dryness of the mucous
membranes 7 85.7 14.3 19 31.6 11.0 P<0.01
Epigastric pains 7 71.4 18.4 18 22.2 10.1 P<0.05
Intestinal murmur after
food 5 100.0 0.0 20 35.0 10.9 P<0.01
Frequent urges to
defecate 7 71.4 18.4 19 21.1 9.6 P<0.01
Fragmented stool 7 100.0 0.0 20 0.0 0.0
Rotten smell of stool 6 83.3 16.7 20 30.0 10.5 P<0.05
Sower smell of stool 6 66.7 21.1 20 0.0 0.0 P<0.01
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