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Date: | Sat, 21 Feb 1998 08:41:08 -0500 |
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<<Disclaimer: Verify this information before applying it to your situation.>>
Mary Anne Cripe's question was:
" does that mean I could be getting damage without knowing it because I have
no obvious reaction?"
Based on our studies a typical (biopsy proven flat mucosa, proved immune
reactions to gluten) gluten intolerant patient does not react immediately
with clinical symptoms for a gluten challenge (J Pediatr Gastroenterol Nutr
1989, 9:176-180).. However, ingestion of GRAMS OF GLUTEN causes several
changes in the intestine.
1. There is an accumulation of inflammatory cells
2. One cell type -so called mast cells- releases factors which factors in
long-term damage the villi and they also release a factor which
3. Increases the permeability -leakiness- of the intestine, which is a
temporarily change after a single ingestion but may be permanent after
repeat dietary mistakes.
I hope it answers your question,
Karoly Horvath, M.D., Ph.D.
Baltimore
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