Mime-Version: |
1.0 |
Sender: |
|
Subject: |
|
From: |
|
Date: |
Sat, 10 Jan 1998 11:22:35 -0500 |
Content-Transfer-Encoding: |
7bit |
Content-Type: |
text/plain; charset=us-ascii |
Reply-To: |
|
Parts/Attachments: |
|
|
Ed wrote:
>What levels does the study suggest is needed for
>lowering Lp(a) levels?
In (1), they studied the effect of niacin and neomycin combined, but niacin
alone works too (2).
From (1):
"Neomycin (2g/day) reduced low density lipoprotein cholesterol and lipoprotein
Lp(a) concentrations by 23% and 24%, respectively. Combination
therapy with neomycin (2 g/day) and niacin (3 g/day) induced a 48%
decline in low density lipoprotein cholesterol levels and a 45% reduction
in the concentration of lipoprotein Lp(a)"
From (2):
"This study examines the effect of nicotinic acid (1 g t.d.s.) on serum
Lp(a) concentration in a group of patients with type II hyperlipidaemia
selected on the basis of a plasma Lp(a) concentration greater than 30
mg/dl. Reductions in total cholesterol, triglyceride, LDL-cholesterol
and Lp(a) were 16.3%, 25.5%, 23.7% and 36.4%, respectively, with an
increase in HDL cholesterol of 37.3%."
1. Gurakar A, et al., Levels of lipoprotein Lp(a) decline with neomycin and
niacin treatment, Atherosclerosis. 1985 Nov 1; 57(2-3): 293-301.
2. Seed M, et al., The effect of nicotinic acid and acipimox on lipoprotein(a)
concentration and turnover.
|
|
|