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I have taken 600 mg. per day plus a B6 shot once a week for the past year,
and 400 mg. per day for at least the past 10 years. I have various symptoms
of a B6 deficiency.  The main one that it keeps under control is the pain
and cramping I get from Carpal Tunnel Syndrome.  I have never noticed any
neuro problems from taking that much.  My doctor is very aware of how much
I am taking.