The team scanned a
> database of human gene sequences and found just one closely related
to
> daf-2: the insulin receptor gene, which helps dispose of dietary
sugar in
> the blood.
> Corbie
>
I had this reference stored and I think it ties in with your article.
It certainly could be yet another reason to keep low carb and keep
a tight control on blood glucose. Yet another reason why I think
too much attention is placed on diabetes, the end stage, and not on
the lack blood sugar control that leads up to it long before it
becomes diabetes.
Gary
Title
Genetic influences on glucose neurotoxicity, aging, and diabetes:
a possible role for glucose hysteresis.
Author
Mobbs CV
Address
Fishberg Center for Neurobiology, Mt. Sinai School of Medicine,
New York, NY 10129.
Source
Genetica, 1993, 91:1-3, 239-53
Abstract
Glucose may drive some age-correlated impairments and may mediate
some effects of dietary restriction on
senescence. The hypothesis that cumulative deleterious effects of
glucose may impair hypothalamic neurons
during aging, leading to hyperinsulinemia and other
age-correlated pathologies, is examined in the context of
genetic influences. Susceptibility to toxic effects of
gold-thio-glucose (GTG) is correlated with longevity
across several mouse strains. GTG and chronic hyperglycemia
induce specific impairments in the
ventromedial hypothalamus similar to impairments which occur
during aging. GTG and a high-calorie diet
both induce chronic hyperinsulinemia, leading initially to
hypoglycemia, followed by the development of
insulin resistance and hyperglycemia. Aging in humans and rodents
appears to entail a similar pattern of
hyperinsulinemia followed by insulin resistance. In humans,
genetic susceptibility to high-calorie diet-induced
impairments in glucose metabolism is extremely common in many
indigenous populations, possibly due to
the selection of the 'thrifty genotype'. It is suggested that the
'thrifty genotype' may entail enhanced sensitivity
to the neurotoxic effects of glucose, and may represent an
example of antagonistic pleiotropy in human
evolution. These data are consistent with the hypothesis that
genetic susceptibility of hypothalamic neurons
to the cumulative toxic effects of glucose (glucose neurohumoral
hysteresis) may correlate with genetic
influences on longevity.
_____________________________________________________________________
Sent by RocketMail. Get your free e-mail at http://www.rocketmail.com
|