"Ketones also have a direct inhibitory effect on lipolysis in adipose 
tissue."

I thought ketones *stimulated* lipolysis in adipose tissues? Or am I 
missing something?

Naomi


Ron Hoggan wrote:
>  Hi Trish,
> As a type II diabetic you have little risk of developing ketoacidosis. 
> Here is a direct quote from a paper by Anssi H. Manninen that appeared 
> in Journal of the International Society of Sports Nutrition. 
> 1(2):7-11, 2004. (www.sportsnutritionsociety.org) under the title 
> "METABOLIC EFFECTS OF THE VERY-LOW-CARBOHYDRATE DIETS: MISUNDERSTOOD 
> “VILLAINS” OF HUMAN METABOLISM"
>
>
> DIABETIC KETOACIDOSIS VS. DIETARY KETOSIS
> Diabetic patients know that the detection in their urine of the ketone 
> bodies is a danger signal that their diabetes is poorly controlled. 
> Indeed, in severely uncontrolled diabetes, if the ketone bodies are 
> produced in massive supranormal quantities, they are associated with 
> ketoacidosis. In this life-threatening complication of diabetes 
> mellitus, the acids 3-hydroxybutyric acid and acetoacetic acid are 
> produced rapidly, causing high concentrations of protons, which 
> overwhelm the body’s acid-base buffering system. *However, during very 
> low carbohydrate intake, the regulated and controlled production of 
> ketone bodies causes a harmless physiological state known as dietary 
> ketosis. In ketosis, the blood pH remains buffered within normal 
> limits. Ketone bodies have effects on insulin and glucagon secretions 
> that potentially contribute to the control of the rate of their own 
> formation because of antilipolytic and lipolytic hormones, 
> respectively. Ketones also have a direct inhibitory effect on 
> lipolysis in adipose tissue.* Interestingly, the effects of ketone 
> body metabolism suggest that mild ketosis may offer therapeutic 
> potential in a variety of different common and rare disease states . 
> The large categories of disease for which ketones may have therapeutic 
> effects are: 1) diseases of substrate insufficiency or insulin 
> resistance; 2) diseases resulting from free radical damage; and 3) 
> disease resulting from hypoxia.
>
> This is an unfortunate myth that has its roots in many medical 
> students being taught that the terms ketosis and ketoacidosis are the 
> same thing.
>
> I hope that helps.
> best wishes,
> Ron
>
>