<<Disclaimer: Verify this information before applying it to your situation.>>

I received a lot of responses about the NSAIDs issue. Some say it caused no
problems, others were against their use. This will require a little further
research on my part, but here are the responses. Thank you for taking the
time to respond to my email.

 

So sorry to hear about your issue!  No as celiacs we are not to take NSAIDs,
because of the leaky gut with celiac.  I have taken them in low doses with
pain pills and don't have to bad of issues as long is it is short term.  All
that happens for me is I get joint pain from them, and not where I have the
arthritis pain I am taking them for.  It is one of the hard issues facing
celiacs!  It is up to you but a few days might be worth it.  Maybe if you
google celiac and nsaid you will find the post I am pretty sure it is in
Peter Greens book too.

 

I take Aleve without any problems.   I take 2 at a time.

 

I am very leery of NSAIDs as they were what triggered my celiac in the first
place.   Am always careful of anything stomach irritant as a result.  Don't
think they cause any problem with bacterial overgrowth, though. 

 

I'm not a doctor nor am I an expert. I can share what I use for inflammation
but please realize it may not work for you. I take Serrapeptase which takes
away the inflammation pain. But I discovered that I had to reduce my daily
dose to 4 times a week because it also cleans out your sinuses. My sinuses
were beginning to hurt.  My partner takes it for a spasm he has in his leg
and it also seems to work for him. By the way, Serrapeptase is an enzyme
that is similar to the one produced by a silk worm for escaping their
cocoon. It's available as an over the counter supplement. 

 

Hi Lori.  I have to say that I've never heard that people with CD should not
take NSAIDs, nor have I ever heard it has anything to do with bacterial
overgrowth.  I'll certainly be interested to hear if others tell you they
are a problem! NSAIDs have other risks, but I think those are the same for
everyone.  If you are taking a daily aspirin to prevent stroke and heart
attacks, you should speak to your physician about combining NSAIDs and
aspirin -- sometimes it is not recommended, or the doctor may have specific
dosage/timing information to give you.  I also do not think a moderate 5-day
dosage of an NSAID should be of much concern.  This is very
conservative.This article is what I've typically seen regarding the risks
associated with NSAIDs:

 <http://www.arthritis.org/cvd-nsaid.php>
http://www.arthritis.org/cvd-nsaid.php I think, if taken in huge doses for a
long time, they can also increase one's risk of kidney problems/disease.

 

I had a brain tumor removed in 2007, and there is a WHOLE lotta ongoing pain
and tissue inflammation associated with that.  I take NSAIDs, though I try
to not take them more than once a day, and restrict it to 2 over-the-counter
tablets if possible.  Having been on steroids a couple of times since that
surgery -- I think the NSAIDs are a far LESSER risk than those.  Steroids
are EVIL.  They help the pain when you are on them, but the side effects and
potential health risks just aren't worth it, unless it is the only
alternative left.  For pain, after the surgery, I was also given a
combination of a narcotic and tylenol (these go by various Rx names: Norco,
Oxycontin, etc.).  This was very effective, but made me too out of it -- so
(with the encouragement of my doctor) I ultimately switched off these pills
and onto NSAIDs.  Also, tylenol IS quite risky, in terms of potential liver
damage.

 

The ONLY associated thing I've ever heard about NSAIDs is some have said
that they can aggravate Dermatitis Herpetiformis, which is a skin disease
caused by celiac disease.  I have DH and the jury on this is still out as
far as I'm concerned.  I don't find that taking ibuprofen makes this problem
any worse.  I might also add that, when I've been accidentally dosed with
gluten (which will make me extremely ill in my gut), the ibuprofen helps
with the gut inflammation -- big time.

 

I think it is hard on stomachs and the GI system

 

Advil is gluten free.

 

First, the NSAID should be gluten-free.  That said, there are a lot of them
on the market (I work in a pharmacy), and different ones work better for
different conditions and different patients. I take diclofenac for my
arthritis pain, but found that Ultram and Daypro do not work for me - one
made me itch and one did nothing for my pain. I have had no problem with
reactions between my NSAID and celiac.

 

Short term use of steroids is not a problem taper up and taper down. I don't
know about NSAIDS.

 

I'm not sure if this is what you heard, but NSAIDs are implicated in the
development of collagenous sprue/microscopic colitis/ collagenous colitis
etc.  Collagenous sprue might actually be what we call refractory sprue or
refractory celiac.  If you goggle these terms you will see the articles. 

Tylenol is ok.

 

You should be fine with ibuprofen, provided you're not taking other
medications that are hard on the kidneys.  Tylenol causes liver damage if
you drink alcohol.  

 

Did your Dr specify which ones?  Years ago it was believed we couldn't take
Aleve, but we can. However the dosage the Dr recommended is way too high for
Aleve.  I would call & ask if plain aspirin or an Advil type is what he
means. I don't know a lot about the bacterial overgrowth, but I don't
remember seeing anything about pain killers in what I have seen.   I agree
steroids should be last resort.

 

Hi Lori, 
NSAIDs cause vascular leakage (1) exacerbating intestinal bleeding caused by
gluten in celiac disease (2,3).  Further, NSAIDs often exacerbate leaky gut,
especially in short-term regimens (4) and should therefore be avoided,
especially in the context of celiac disease. 

1. Lanas A.A review of the gastrointestinal safety data--a
gastroenterologist's perspective. Rheumatology (Oxford). 2010 May;49 Suppl
2:ii3-10.
2. Tielemans MM, Eikendal T, Jansen JB, van Oijen MG.Identification of NSAID
users at risk for gastrointestinal complications: a systematic review of
current guidelines and consensus agreements. Drug Saf. 2010 Jun
1;33(6):443-53.
3. Fine KD. The prevalence of occult gastrointestinal bleeding in celiac
sprue. N Engl J Med. 1996 May 2;334(18):1163-7.
4. Campanella C, Jamali F.Influence of prolonged exposure of a short half
life non-steroidal anti-inflammatory drugs on gastrointestinal safety.
Inflammopharmacology.  2009 Aug;17(4):205-10. Epub 2009 Jul 8.

Short term use of steroids may invovle less risk. 

NSAIDS irritate and I can't take any of them, tried. It gave me a hiatal
hernia which I have to this day since my surgery. Steroids in oral form do
the same thing. I know, I took them too on low dose for a week and had to
stop.

 

 

 

 

 

 


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