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Wed, 4 Jun 1997 22:00:49 -0500 |
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Muriel Hykes wrote:
> >I did a paperchase search last night and obtained 33 citations on PST.
> >Am loking over them closely. Did find a reference to modulation to PST
> >by quercetin the bioflavanoid from the rutin family. Quercetin
> >downregulates PST. Will keep you abreast.
>
> Quercetin also prevents degranulation of the mast cells, which therefore
> cannot release histamine. Perhaps it acts by this mechanism. I take it for
> allergies.
Quercetin has been shown to be a powerful inhibitor of phospholipase A2
which is the enzyme responsible for "clipping" arachidonic acid from the
cells' phopholipid bilayer. This cascade of reactions beginning with
phopholipase A2 is what initiates AA's role in mast cell degranulation.
Andrew =8-)
--
Andrew S. Bonci, BA, DC, DAAPM
Assistant Professor, Department of Diagnosis
Cleveland Chiropractic College
6401 Rockhill Road
Kansas City, Missouri 64131
(816) 333-7436 ex39
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