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From:
Meir Weiss <[log in to unmask]>
Reply To:
Cerebral Palsy List <[log in to unmask]>
Date:
Tue, 21 Feb 2012 08:58:20 -0500
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http://www.alleninstitute.org/Media/documents/press_releases/2011_1103_Press
Release_DataRelease.html

Allen Institute for Brain Science launches new brain atlas and updates four
others with new data and tools

View/download PDF

November 3, 2011 - The Allen Institute for Brain Science announced today the
launch of a new brain atlas resource and updates to four existing resources,
all publicly available online to accelerate brain research around the globe.
The new atlas, the Allen Mouse Brain Connectivity Atlas, moves the Allen
Institute's mapping efforts beyond its historical focus on gene expression
toward neural circuitry. Additional updates include enhancements to the
Allen Mouse Brain Atlas, the Allen Human Brain Atlas, the NIH Blueprint
Non-Human Primate (NHP) Atlas, and the BrainSpan Atlas of the Developing
Human Brain.
New Atlas Resource - Allen Mouse Brain Connectivity Atlas

 
The Allen Mouse Brain Connectivity Atlas is a three-dimensional,
high-resolution map of neural connections throughout the mouse brain.
Generated on a standardized platform, the Atlas is designed as a
comprehensive interactive database of the information highways, called
axonal projections, that link different brain areas to form the circuits
responsible for behavior, perception and other brain functions. This
foundational map will help scientists understand how the brain is wired,
offering new insights into how the brain works and what goes awry in brain
diseases and disorders.
 
"We are delighted to get this first batch of connectivity data into the
hands of the broader research community," said Allan Jones, Ph.D., chief
executive officer of the Allen Institute for Brain Science. "We look forward
to expanding this unique dataset significantly as the project continues."
 
This first data release includes an initial set of high-resolution images
detailing axonal projections and anatomic reference data. The Atlas will be
enhanced with additional data and more tools for data mining and
visualization in subsequent data releases.
 

Other Updates


The Allen Mouse Brain Atlas is a genome-wide, three-dimensional map of gene
expression throughout the adult mouse brain. Completed in 2006, the Atlas
has now been revamped to update the underlying technologies and leverage
tools developed for other more recent atlases in the Allen Brain Atlas
portfolio. Enhancements include new search and visualization features, such
as an upgrade to the Brain ExplorerR 3-D viewer that offers expanded
anatomic detail, and an upgraded, fully-digitized and interactive reference
atlas.

The Allen Human Brain Atlas is a multi-modal, three-dimensional map of the
human brain that integrates anatomic and gene expression data throughout the
adult human brain. With data for two complete brains available last spring,
the latest data release adds the first batch of data from a third brain,
specifically 110 new microarray samples. Because individual brains differ,
the ability to compare data from multiple brains is important for
understanding what features are common across individuals. Additional
updates include enhancements to the user-interface and visualization
functions improve usability.

The NIH Blueprint NHP Atlas offers a unique set of data and tools to explore
the cellular and molecular architecture of the postnatal developing primate
brain. This release adds microarray data and associated search and
visualization tools. Additional in situ hybridization data generated
serially across hemispheres and corresponding downloadable magnetic
resonance images are now also available.

The BrainSpan Atlas of the Developing Human Brain, created by a research
consortium and made publicly available online via the Allen Brain Atlas data
portal, provides broad and detailed anatomic analysis of gene expression
across human brain development. The atlas has been expanded with new
microarray data for 287 structures, complete with an interactive heat map
viewer for browsing those data, and an anatomic reference atlas for one
developmental stage.

About the Atlases

The Allen Brain Atlas resources, created by the Allen Institute for Brain
Science as open online public resources, integrate large-scale,
systematically generated gene expression and anatomic datasets, complete
with powerful search and viewing tools. Each month, the Allen Brain Atlas
resources receive approximately 45,000 visits from researchers worldwide.
Regular updates and data releases put an increasing amount of valuable data
and powerful search and viewing tools in the hands of scientists and
research organizations everywhere, thereby accelerating understanding of the
brain and related disorders and diseases. The Allen Institute's next public
data release is scheduled for March 2012. 

The NIH Blueprint Non-Human Primate (NHP) Atlas,
http://www.blueprintnhpatlas.org, is funded by NIH Contract
HHSN-271-2008-0047 to the Allen Institute for Brain Science (Seattle, WA)
totaling $8.5M. The content is solely the responsibility of the authors and
does not necessarily represent the official views of the National Institutes
of Health. This project is funded with 100% federal funds. No non-government
funds support the project.

The BrainSpan Atlas of the Developing Human Brain is supported by grants
from the National Institute of Mental Health to the Allen Institute for
Brain Science (award number RC2MH089921), the University of Southern
California (award number RC2MH090047), and Yale University (award number
RC2MH089929), totaling $16.2M, $8.9M and $9.9M, respectively. This project
is funded with 100% federal funds. No non-government funds support the
project. The content is solely the responsibility of the respective authors
and does not necessarily represent the official views of the National
Institute of Mental Health or the National Institutes of Health.

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