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Subject:
From:
Greg De Guzman <[log in to unmask]>
Reply To:
Thyroid Discussion Group <[log in to unmask]>
Date:
Mon, 3 Mar 2003 10:11:46 +0800
Content-Type:
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----- Original Message -----
From: "Cathy Brown" <[log in to unmask]>


> My question is this.does Synthroid relieve the Wilsons symptoms?    I am
so full of
> questions and eagerness to learn how to deal with the health problems.

Since there is already a Diagnosis, let's take that as a given for now..
Thyroid treatment, depending on the symptoms, is an escalating scale. Your
dose of 50 mcgs is still not the recommended starting dose, but that does
not mean to fault your Dr. It is likely that your dose is still being
titrated until you reach the optimum for your case. You should inform your
dr. when symptoms persist or resolve at a particular dosage.

Wilson's Syndrome proposes a faulty conversion of Thyroxine to the active
Triodothyronine. Their model is based on sub-optimum body temperature
causing faulty fit of most enzymatic processes to their substrates, as
explained therough the Michaelis-Menten Theory (key like fit bet substrates
and enzyme molecules).
So, to answer your question.. Based on the Wilson approach, a faulty T4 to
T3 conversion excludes Throxine. This school of thought proposes the
accumulation of Reverse T3 from this faulty T4 to T3 conversion. They base
their treatment on the use of multi dosing using and cycling Time-released
T3 to generate an essential optimum body temperature. After several cycles
it is hoped that patients could eventually taper off the dosage, sometimes
to even nil.

Currenrt mainstream researches however found recent evidence that T4 to T3
conversion is mediated by Selenium. Enzymes responsible for thyroid
metabolism are seleno-proteins. It is also demonstrated that the
accumulation of Reverse T3 is cuased by this anomalous T4 to T3 conversion
as well as a faulty T3 to metabolite breakdowns.

I would reserve the opinion to wait until your Dr. has reached an optimum
level before considering other alternatives.

Good luck..

Greg

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