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| Date: | Fri, 20 Mar 2009 08:54:28 -0400 |
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A medical journal article published today in Alimentary Pharmacology &
Therapeutics caught my eye:
Clinical trial: B vitamins improve health in patients with coeliac disease
living on a gluten-free diet
C. HALLERT, M. SVENSSON, J. THOLSTRUP, B. HULTBERG
Abstract
Published Online: 20 Jan 2009
DOI 10.1111/j.1365-2036.2009.03945.x
Here is the abstract:
ABSTRACT
Background Patients with coeliac disease living on a gluten-free diet show
vitamin deficiency and reduced subjective health status.
Aim To study the biochemical and clinical effects of B vitamin
supplementation in adults with longstanding coeliac disease.
Methods In a double blind placebo controlled multicentre trial, 65 coeliac
patients (61% women) aged 45–64 years on a strict gluten-free diet for
several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg
cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome
measures were psychological general well-being (PGWB) and the plasma total
homocysteine (tHcy) level, marker of B vitamin status.
Results Fifty-seven patients (88%) completed the trial. The tHcy level was
baseline median 11.7 ́mol/L (7.4–23.0), significantly higher than in
matched population controls [10.2 ́mol/L (6.7–22.6) (P < 0.01)]. Following
vitamin supplementation, tHcy dropped a median of 34% (P < 0.001),
accompanied by significant improvement in well-being (P < 0.01), notably
Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor
well-being.
Conclusions Adults with longstanding coeliac disease taking extra B
vitamins for 6 months showed normalized tHcy and significant improvement in
general well-being, suggesting that B vitamins should be considered in
people advised to follow a gluten-free diet.
I read the abstract at this link:
http://www3.interscience.wiley.com/journal/121645337/abstract?CRETRY=1&SRETRY=0
(you may need to register but there is no fee)
A personal note: I definitely noticed an improvement personally when I
started taking B vitamins (memory, concentration) several years ago after
going GF. However, don't take too much!! I became Vitamin B6 toxic on
only 50mg/day - resulting in peripheral neuropathy and loss of sensation in
my feet.
Happy weekend,
Becky
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