Yes, studies have shown that AGEs in foods contribute to AGEs in the body. There are various studies showing that a low-AGE diet contributed to lower overall levels of AGEs in the body for example:-
http://jasn.asnjournals.org/cgi/content/full/14/3/728
Exercise can reduce symptoms related to AGEs on a temporary basis, but exercise can't really compensate for a bad diet in the long-term. That is, if someone is on a bad diet, they're likely to end up unhealthy enough not to be able to or want to exercise in the first place.
Re acetyl-l-carnosine :- I'm extremely doubtful of the efficacy of processed supplements, given that they are notoriously ineffective. As for acetyl-l-carnosine in meats, sure that would reduce the chances of glycation-related issues re AGEs to some extent but there are of course other heat-created toxins such as heterocyclic amines(present in cooked muscle-meats and cigarette smoke primarily), polycyclic aromatic hydrocarbons and nitrosamines( the last one being more an issue with smoked/processed meats, I believe). Plus, there are also ALEs(otherwise known as Advanced Lipoxidation End products(not derived from sugar), which are a major issue with cooked animal foods, so avoiding sugars isn't too effective.
Geoff
> Date: Tue, 19 Jan 2010 17:20:47 -0600
> From: [log in to unmask]
> Subject: Re: Arthritis question...
> To: [log in to unmask]
>
> Geoff:
>
> You've raised an interesting item: do consumed glycatinated substances
> contribute to AGEs in vivo?
>
> One powerful intervention for preventing, possibly reversing AGEs is
> interval strength training; moreover, that method results in upwards of 25%
> greater carnosine stores assuming supplementation with beta-alanine.
> Supplemental carnosine is likewise effective.
>
> Recently published studies indicate cataracts result from AGEs, while
> topical administration of acetyl-l-carnosine has been shown to arrest
> further cataract development, and in some cases reverse it. Best bet is to
> eliminate sugars from the diet altogether.
>
> On Tue, Jan 19, 2010 at 4:29 PM, Geoffrey Purcell
> <[log in to unmask]>wrote:
>
> > I wouldn't be surprised if cooked palaeo had a small effect. After all,
> > many highly processed foods contribute heavily to inflammation, not just
> > cooked foods in general.
> >
> >
> >
> > As for cooking meat rare, that does reduce the amounts of AGEs, and
> > therefore the symptoms, to some extent. It's certainly not as effective as
> > raw, but it's still a major improvement on eating meats well-done.
> >
> > Some palaeos who don't identify themselves as rawpalaeo as such, don't seem
> > to mind only searing the meats on the outside for a short period but leaving
> > the meats largely raw on the inside.
> >
> >
> >
> > Geoff
> >
> >
> >
> >
> >
> >
> >
> >
> > > Date: Tue, 19 Jan 2010 14:05:12 -0500
> > > From: [log in to unmask]
> > > Subject: Re: Arthritis question...
> > > To: [log in to unmask]
> > >
> > > Thanks for all the links, Geoff. Very interesting (and a bit
> > > disheartening) reading! Suggesting raw fruits & veggies is easy enough
> > > but I don't think raw meat is going to fly. Would it be of any benefit
> > > to cook the meat as rare as palatable, not allowing it to brown?
> > > Wouldn't that reduce the AGE's?
> > > I just turned 48 yesterday so I can see what's coming. I eat most of my
> > > veggies raw, all fruits raw, but raw meat has been the stickler for me.
> > > I used to be a well-done girl, then went to med-well, then med. and now
> > > I am down to med.-rare. Do you feel that while not perfect, I am on the
> > > right track? This I might be able to push on my picky non-paleo sisters.
> > >
> > > Stevie
> > >
> > > On 1/19/2010 4:21 AM, Geoffrey Purcell wrote:
> > > > A cooked, palaeolithic diet wouldn't be any good for getting rid of
> > osteoarthritis. This is because it's been pointed out that modern
> > hunter-gatherers on traditional diets also get osteoarthritis, even if they
> > eat a cooked palaeo diet:-
> > > >
> > > >
> > > >
> > > >
> > > > http://en.wikipedia.org/wiki/Paleolithic_diet#Observational_studies
> > > >
> > > >
> > > >
> > > > Given that heat-created toxins derived from cooked foods, specifically
> > advanced glycation end products(aka "AGEs"), are routinely linked to general
> > age-related inflammation, and the number of studies done on the connection
> > between AGEs and osteoarthritis:-
> > > >
> > > >
> > > >
> > > > http://www.ncbi.nlm.nih.gov/pubmed/11822407
> > > >
> > > >
> > > >
> > > > http://arthritis-research.com/content/6/S3/78
> > > >
> > > >
> > > >
> > > >
> > http://www3.interscience.wiley.com/journal/107642826/abstract?CRETRY=1&SRETRY=0
> > > >
> > > >
> > > >
> > > >
> > > >
> > > > http://www.febsletters.org/article/S0014-5793(07)00368-7/abstract<http://www.febsletters.org/article/S0014-5793%2807%2900368-7/abstract>
> > > >
> > > >
> > > >
> > > > going rawpalaeo(ie raw meat, raw fruit/raw veg) would be more likely to
> > work than any other method.
> > > >
> > > >
> > > >
> > > > Geoff
> > > >
> > > >
> > > >
> > > >
> > > >
> > > >
> > > >> Date: Mon, 18 Jan 2010 16:19:46 -0500
> > > >> From: [log in to unmask]
> > > >> Subject: Arthritis question...
> > > >> To: [log in to unmask]
> > > >>
> > > >> Hello everyone. This may be sort of off topic and I apologize in
> > advance
> > > >> if it is. I have read that paleo eating can help rheumatoid arthritis,
> > > >> but haven't really found anything saying it's of benefit to
> > > >> osteoarthritis--the wear and tear on joints as we age. Three of my
> > > >> sisters have osteoarthritis and I've been trying to find info to help
> > > >> them alleviate pain/inflammation and possibly to prevent further
> > > >> deterioration of the joint.
> > > >>
> > > >> I'd appreciate any links, suggestions and/or personal experiences of
> > > >> what may help.
> > > >>
> > > >> Thanks
> > > >> Stevie
> > > >>
> > > >
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