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Subject:
Rotavirus May Increase Celiac Disease Risk
From:
Roy Jamron <[log in to unmask]>
Reply To:
Roy Jamron <[log in to unmask]>
Date:
Sat, 14 Oct 2006 01:47:02 -0400
Content-Type:
text/plain
Parts/Attachments:
text/plain (54 lines) 
<<Disclaimer: Verify this information before applying it to your situation.>>

A previous study found a molecular mimicry mechanism may associate a 
rotavirus protein with celiac disease.  Now a new study of rotavirus 
antibodies in 1,931 children carrying HLA alleles for celiac disease in 
the Denver metropolitan area seems to show that the risk of developing 
celiac disease increases as the frequency of rotavirus infection 
increases.  The study followed children from infancy, taking blood samples 
at 9, 15, and 24 months and annually, thereafter.  54 children developed 
celiac disease at a median age of 4.4 years. The study found "Frequent 
rotavirus infections predicted a higher risk of celiac disease 
autoimmunity (compared with zero infections, rate ratio 1.94, 95% 
confidence interval [CI] 0.39-9.56, for one infection and rate ratio 3.76, 
95% CI 0.76-18.7, for 2 or more infections, rate ratio for trend per 
increase in number of infections = 1.94, 95% CI 1.04-3.61, p= 0.037)."

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Am J Gastroenterol. 2006 Oct;101(10):2333-40.
Rotavirus infection frequency and risk of celiac disease autoimmunity in 
early childhood: a longitudinal study.Stene LC, Honeyman MC, Hoffenberg 
EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth 
GS, Rewers M. 
Barbara Davis Center for Childhood Diabetes, University of Colorado School 
of Medicine, Aurora, Colorado.

< http://dx.doi.org/10.1111/j.1572-0241.2006.00741.x >

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Previous study:

PLoS Medicine Volume 3, Issue 9, SEPTEMBER 2006 
In Celiac Disease, a Subset of Autoantibodies against Transglutaminase 
Binds Toll-Like Receptor 4 and Induces Activation of Monocytes
Giovanna Zanoni, Riccardo Navone, Claudio Lunardi, Giuseppe Tridente, 
Caterina Bason, Simona Sivori, Ruggero Beri, Marzia Dolcino, Enrico 
Valletta, Roberto Corrocher, Antonio Puccetti 

Editor's Summary (READ FIRST!)
< http://dx.doi.org/10.1371/journal.pmed.0030358#editor >

Full Text
< http://dx.doi.org/10.1371/journal.pmed.0030358 >

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